The impact of HIV-1 within-host evolution on transmission dynamics

The adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within...

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Autores:
Tipo de recurso:
Fecha de publicación:
2018
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23826
Acceso en línea:
https://doi.org/10.1016/j.coviro.2017.12.001
https://repository.urosario.edu.co/handle/10336/23826
Palabra clave:
Chemokine receptor CCR5
Chemokine receptor CXCR4
Bottleneck population
CD4 lymphocyte count
Disease course
Genetic distance
Genetic variability
Host pathogen interaction
Human
Human immunodeficiency virus 1
Molecular epidemiology
Molecular evolution
Nonhuman
Phylogeny
Priority journal
Review
Viral genetics
Virus load
Virus morphology
Virus transmission
Virus virulence
Epidemic
Genetics
Host pathogen interaction
Human immunodeficiency virus 1
Human immunodeficiency virus infection
Molecular evolution
Pathogenicity
Theoretical model
Transmission
Virulence
Epidemics
HIV Infections
HIV-1
Host-Pathogen Interactions
Humans
Virulence
Molecular
Theoretical
Evolution
Models
Rights
License
Abierto (Texto Completo)
Description
Summary:The adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within-host virulence and between-host infectiousness. This trade-off is visible in the disparity in evolutionary rates at within-host and between-host levels, and preferential transmission of ancestral donor viruses. Understanding the impact of within-host evolution for epidemiological studies is essential for the design of preventive and therapeutic measures. Herein, we review recent theoretical and experimental work that generated new insights into the complex link between within-host evolution and between-host fitness, revealing temporal and selective processes underlying the structure and dynamics of HIV-1 transmission. © 2017 Elsevier B.V.