Mapping the anatomy of a Plasmodium falciparum MSP-1 epitope using pseudopeptide-induced mono- and polyclonal antibodies and CD and NMR conformation analysis

Antigen structure modulation represents an approach towards designing subunit malaria vaccines. A specific epitope's ? carbon stereochemistry, as well as its backbone topochemistry, was assessed for obtaining novel malarial immunogens. A variety of MSP-138–61 Plasmodium falciparum epitope pseud...

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Autores:

Tipo de recurso:

Fecha de publicación:

2004

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/28112

Acceso en línea:

https://doi.org/10.1016/j.jsb.2004.04.010
https://repository.urosario.edu.co/handle/10336/28112

Palabra clave:

Molecular mimicry
Merozoite surface protein-1 (MSP-1)
Pseudopeptide
Topology
Stereochemistry

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