HIV Controllers Exhibit Effective CD8 + T Cell Recognition of HIV-1-Infected Non-activated CD4 + T Cells

Even with sustained antiretroviral therapy, resting CD4 + T cells remain a persistent reservoir of HIV infection, representing a critical barrier to curing HIV. Here, we demonstrate that CD8 + T cells recognize infected, non-activated CD4 + T cells in the absence of de novo protein production, as me...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23642
Acceso en línea:
https://doi.org/10.1016/j.celrep.2019.03.016
https://repository.urosario.edu.co/handle/10336/23642
Palabra clave:
T lymphocyte receptor
Antigen presentation
Article
CD4+ T lymphocyte
CD8+ T lymphocyte
Colorimetry
Controlled study
Cytokine production
Degranulation
Flow cytometry
Fluorescence microscopy
Fluorescence resonance energy transfer
Human
Human cell
Human immunodeficiency virus 1 infection
Immune response
Immunological synapse
Long terminal repeat
Molecular recognition
Priority journal
Protein cleavage
Protein protein interaction
Synapse
Virus entry
Virus genome
Virus particle
Cytotoxic T lymphocytes
Elite controllers
Granzyme
HIV
HIV cure
HLA
Immunologic synapse
Perforin
Rights
License
Abierto (Texto Completo)