Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study

Systemic lupus erythematosus (SLE) is a chronic heterogeneous autoimmune disorder characterized by the loss of tolerance to self-antigens and dysregulated interferon responses. The etiology of SLE is complex, involving both heritable and environmental factors. Candidate-gene studies and genome-wide...

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Autores:

Tipo de recurso:

Fecha de publicación:

2012

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/18736

Acceso en línea:

http://repository.urosario.edu.co/handle/10336/18736

Palabra clave:

Autoantigen
Ikaros Transcription Factor
Interferon
Interferon Consensus Sequence Binding Protein
Membrane Protein
Protein Ikzf3
Transmembrane Protein 39A
Unclassified Drug
Zona Pellucida Binding Protein 2
Adamtsl1 Gene
African American
American Indian
Asian
C1Orf64 Gene
Cadm2 Gene
Cfhr1 Gene
Chromosome 17Q
Controlled Study
Environmental Factor
Ethnicity
European American
Fam19A2 Gene
Gene
Gene Identification
Gene Locus
Gene Mapping
Gene Sequence
Genetic Association
Genetic Risk
Genetic Susceptibility
Genetic Variability
Genome Analysis
Genotype
Haplotype
Heritability
High Risk Population
Hispanic
Human
Ikzf3 Gene
Il12A Gene
Immune Response
Immunological Tolerance
Immunoregulation
Irf8 Gene
Loc6392 Gene
Lpp Gene
Major Clinical Study
Or8D4 Gene
Priority Journal
Single Nucleotide Polymorphism
Slu7 Gene
Stxbp6 Gene
Systemic Lupus Erythematosus
Tmem39A Gene
Zpbp2 Gene
African Continental Ancestry Group
Asian Continental Ancestry Group
Chromosome Mapping
Egg Proteins
European Continental Ancestry Group
Genetic Predisposition To Disease
Haplotypes
Hispanic Americans
Ikaros Transcription Factor
Interferon Regulatory Factors
Male
Membrane Proteins
Single Nucleotide
Dna
North American
Systemic
Indians
Lupus Erythematosus
Polymorphism
Sequence Analysis
Article
Female
Humans
Lupus eritematoso sistémico
Genética
Patología

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