Concordance of CCR5 genotypes that influence cell-mediated immunity and HIV-1 disease progression rates

We used cutaneous delayed-type hypersensitivity responses, a powerful in vivo measure of cell-mediated immunity, to evaluate the relationships among cell-mediated immunity, AIDS, and polymorphisms in CCR5, the HIV-1 coreceptor. There was high concordance between CCR5 polymorphisms and haplotype pair...

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Autores:
Tipo de recurso:
Fecha de publicación:
2011
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/22375
Acceso en línea:
https://doi.org/10.1093/infdis/jiq023
https://repository.urosario.edu.co/handle/10336/22375
Palabra clave:
Chemokine receptor CCR5
Virus receptor
Acquired immune deficiency syndrome
Adult
AIDS patient
Allele
Article
Cellular immunity
Cohort analysis
Controlled study
Delayed hypersensitivity
Disease course
Female
Gene expression
Genetic association
Genetic transcription
Genotype
Haplotype
Heterozygosity
Human
Human immunodeficiency virus 1
Human immunodeficiency virus 1 infection
Human immunodeficiency virus infected patient
Immunoregulation
In vivo study
Major clinical study
Male
Nucleotide sequence
Phenotype
Priority journal
Single nucleotide polymorphism
Virus immunity
Virus pathogenesis
Virus replication
Adult
Disease Progression
Female
Genotype
Haplotypes
HIV Infections
HIV-1
Humans
Male
Genetic
Delayed
Cellular
CCR5
Hypersensitivity
Immunity
Polymorphism
Receptors
Rights
License
Abierto (Texto Completo)
Description
Summary:We used cutaneous delayed-type hypersensitivity responses, a powerful in vivo measure of cell-mediated immunity, to evaluate the relationships among cell-mediated immunity, AIDS, and polymorphisms in CCR5, the HIV-1 coreceptor. There was high concordance between CCR5 polymorphisms and haplotype pairs that influenced delayed-type hypersensitivity responses in healthy persons and HIV disease progression. In the cohorts examined, CCR5 genotypes containing -2459G/G (HHA/HHA, HHA/HHC, HHC/HHC) or -2459A/A (HHE/HHE) associated with salutary or detrimental delayed-type hypersensitivity and AIDS phenotypes, respectively. Accordingly, the CCR5-D32 allele, when paired with non-?32-bearing haplotypes that correlate with low (HHA, HHC) versus high (HHE) CCR5 transcriptional activity, associates with disease retardation or acceleration, respectively. Thus, the associations of CCR5-?32 heterozygosity partly reflect the effect of the non-?32 haplotype in a background of CCR5 haploinsufficiency. The correlations of increased delayed-type hypersensitivity with -2459G/G-containing CCR5 genotypes, reduced CCR5 expression, decreased viral replication, and disease retardation suggest that CCR5 may influence HIV infection and AIDS, at least in part, through effects on cell-mediated immunity. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.