PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity
Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Exami...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2018
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/20449
- Acceso en línea:
- https://repository.urosario.edu.co/handle/10336/20449
- Palabra clave:
- Ion Channel
Transcription Factor
Disequilibrium
Genetic Analysis
Genome
Meta-Analysis
Risk Factor
African
Atrial Fibrillation
Atrioventricular Conduction
Cell Junction
Electric Activity
European
Gene Linkage Disequilibrium
Gene Locus
Genome-Wide Association Study
Heart Block
Heart Depolarization
Heart Rate
Human
Missense Mutation
Phenotype
Pr Interval
Qrs Interval
Signal Transduction
Canal de iones
Factor de transcripción
Sangre
Sistema cardiovascular
Enfermedades
Cardiovascular system
Blood
Heart Disease
Article
Enfermedades cardiovasculares
Fibrilación auricular
Bloqueo cardíaco
- Rights
- License
- Abierto (Texto Completo)
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oai:repository.urosario.edu.co:10336/20449 |
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EDOCUR2 |
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|
dc.title.spa.fl_str_mv |
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity |
title |
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity |
spellingShingle |
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity Gudnason, Vilmundur Ion Channel Transcription Factor Disequilibrium Genetic Analysis Genome Meta-Analysis Risk Factor African Atrial Fibrillation Atrioventricular Conduction Cell Junction Electric Activity European Gene Linkage Disequilibrium Gene Locus Genome-Wide Association Study Heart Block Heart Depolarization Heart Rate Human Missense Mutation Phenotype Pr Interval Qrs Interval Signal Transduction Canal de iones Factor de transcripción Sangre Sistema cardiovascular Enfermedades Cardiovascular system Blood Heart Disease Article Enfermedades cardiovasculares Fibrilación auricular Bloqueo cardíaco |
title_short |
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity |
title_full |
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity |
title_fullStr |
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity |
title_full_unstemmed |
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity |
title_sort |
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity |
dc.creator.none.fl_str_mv |
Gudnason, Vilmundur Hayward, Caroline Heckbert, Susan R. Hicks, Andrew A. Jukema, J. Wouter Kääb, Stefan Lehtimäk, Terho Liu, Yongmei Munroe, Patricia B. Parsa, Afshin Polasek, Ozren Psaty, Bruce M. Roden, Dan M. Schnabel, Renate B. Sinagra, Gianfranco Stefansson, Kari Stricker, Bruno H. Harst, Pim van der Duijn, Cornelia M. van Wilson, James F. Gharib, Sina A. Bakker, Paul I.W. de Isaacs, Aaron Arking, Dan E. Sotoodehnia, Nona |
dc.creator.google.spa.fl_str_mv |
van Setten, Jessica Brody, Jennifer A. Jamshidi, Yalda Swenson, Brenton R. Butler, Anne M. Campbell, Harry Del Greco, Fabiola M. Evans, Daniel S. Gibson, Quince Gudbjartsson, Daniel F. Kerr, Kathleen F. Krijthe, Bouwe P. Lyytikäinen, Leo-Pekka Müller, Christian Müller-Nurasyid, Martina Nolte, Ilja M. Padmanabhan, Sandosh Ritchie, Marylyn D. Robino, Antonietta Smith, Albert V. Steri, Maristella Tanaka, Toshiko Teumer, Alexander Trompet, Stella Ulivi, Sheila Verweij, Niek Yin, Xiaoyan Arnar, David O. Asselbergs, Folkert W. Bader, Joel S. Barnard, John Bis, Josh Blankenberg, Stefan Boerwinkle, Eric Bradford, Yuki Buckley, Brendan M. Chung, Mina K. Crawford, Dana den Hoed, Marcel Denny, Josh C. Dominiczak, Anna F. Ehret, Georg B. Eijgelsheim, Mark Ellinor, Patrick T. Felix, Stephan B. Franco, Oscar H. Franke, Lude Harris, Tamara B. Holm, Hilma Ilaria, Gandin Iorio, Annamaria Kähönen, Mika Kolcic, Ivana Kors, Jan A. Lakatta, Edward G. Launer, Lenore J. Lin, Honghuang Lin, Henry J. Loos, Ruth J.F. Lubitz, Steven A. Macfarlane, Peter W. Magnani, Jared W. Mateo Leach, Irene Meitinger, Thomas Mitchell, Braxton D. Munzel, Thomas Papanicolaou, George J. Peters, Annette Pfeufer, Arne Pramstaller, Peter P. Raitakari, Olli T. Rotter, Jerome I. Rudan, Igor Samani, Nilesh J. Schlessinger, David Silva Aldana, Claudia T. Sinner, Moritz F. Smith, Jonathan D. Snieder, Harold Soliman, Elsayed Z. Spector, Timothy D. Stott, David J. Strauch, Konstantin Tarasov, Kirill V. Thorsteinsdottir, Unnur Uitterlinden, Andre G. Van Wagoner, David R. Völker, Uwe Völzke, Henry Waldenberger, Melanie Jan Westra, Harm Wild, Philipp S. Zeller, Tanja Alonso, Alvaro Avery, Christy L. Bandinelli, Stefania Benjamin, Emelia J. Cucca, Francesco Dörr, Marcus Ferrucci, Luigi Gasparini, Paolo Gudnason, Vilmundur Hayward, Caroline Heckbert, Susan R. Hicks, Andrew A. Jukema, J. Wouter Kääb, Stefan Lehtimäki, Terho Liu, Yongmei Munroe, Patricia B. Parsa, Afshin Polasek, Ozren Psaty, Bruce M. Roden, Dan M. Schnabel, Renate B. Sinagra, Gianfranco Stefansson, Kari Stricker, Bruno H. van der Harst, Pim van Duijn, Cornelia M. Wilson,James F. Gharib, Sina A. de Bakker, Paul I.W. Isaacs, Aaron Arking, Dan E. Sotoodehnia, Nona |
author |
Gudnason, Vilmundur |
author_facet |
Gudnason, Vilmundur Hayward, Caroline Heckbert, Susan R. Hicks, Andrew A. Jukema, J. Wouter Kääb, Stefan Lehtimäk, Terho Liu, Yongmei Munroe, Patricia B. Parsa, Afshin Polasek, Ozren Psaty, Bruce M. Roden, Dan M. Schnabel, Renate B. Sinagra, Gianfranco Stefansson, Kari Stricker, Bruno H. Harst, Pim van der Duijn, Cornelia M. van Wilson, James F. Gharib, Sina A. Bakker, Paul I.W. de Isaacs, Aaron Arking, Dan E. Sotoodehnia, Nona |
author_role |
author |
author2 |
Hayward, Caroline Heckbert, Susan R. Hicks, Andrew A. Jukema, J. Wouter Kääb, Stefan Lehtimäk, Terho Liu, Yongmei Munroe, Patricia B. Parsa, Afshin Polasek, Ozren Psaty, Bruce M. Roden, Dan M. Schnabel, Renate B. Sinagra, Gianfranco Stefansson, Kari Stricker, Bruno H. Harst, Pim van der Duijn, Cornelia M. van Wilson, James F. Gharib, Sina A. Bakker, Paul I.W. de Isaacs, Aaron Arking, Dan E. Sotoodehnia, Nona |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
dc.subject.spa.fl_str_mv |
Ion Channel Transcription Factor Disequilibrium Genetic Analysis Genome Meta-Analysis Risk Factor African Atrial Fibrillation Atrioventricular Conduction Cell Junction Electric Activity European Gene Linkage Disequilibrium Gene Locus Genome-Wide Association Study Heart Block Heart Depolarization Heart Rate Human Missense Mutation Phenotype Pr Interval Qrs Interval Signal Transduction Canal de iones Factor de transcripción Sangre Sistema cardiovascular |
topic |
Ion Channel Transcription Factor Disequilibrium Genetic Analysis Genome Meta-Analysis Risk Factor African Atrial Fibrillation Atrioventricular Conduction Cell Junction Electric Activity European Gene Linkage Disequilibrium Gene Locus Genome-Wide Association Study Heart Block Heart Depolarization Heart Rate Human Missense Mutation Phenotype Pr Interval Qrs Interval Signal Transduction Canal de iones Factor de transcripción Sangre Sistema cardiovascular Enfermedades Cardiovascular system Blood Heart Disease Article Enfermedades cardiovasculares Fibrilación auricular Bloqueo cardíaco |
dc.subject.ddc.spa.fl_str_mv |
Enfermedades |
dc.subject.keyword.spa.fl_str_mv |
Cardiovascular system Blood Heart Disease Article |
dc.subject.lemb.spa.fl_str_mv |
Enfermedades cardiovasculares Fibrilación auricular Bloqueo cardíaco |
description |
Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are over-represented in cardiac disease processes including heart block and atrial fibrillation. Variants in over half of the 44 loci were associated with atrial or blood transcript expression levels, or were in high linkage disequilibrium with missense variants. Six additional loci were identified either by meta-analysis of ~105,000 African and European-descent individuals and/or by pleiotropic analyses combining PR interval with heart rate, QRS interval, and atrial fibrillation. These findings implicate developmental pathways, and identify transcription factors, ion-channel genes, and cell-junction/cell-signaling proteins in atrio-ventricular conduction, identifying potential targets for drug development. © 2018, The Author(s). |
publishDate |
2018 |
dc.date.created.none.fl_str_mv |
2018 |
dc.date.issued.none.fl_str_mv |
2018 |
dc.date.accessioned.none.fl_str_mv |
2019-10-17T12:55:20Z |
dc.date.available.none.fl_str_mv |
2019-10-17T12:55:20Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41467-018-04766-9 |
dc.identifier.issn.none.fl_str_mv |
2041-1723 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/20449 |
identifier_str_mv |
10.1038/s41467-018-04766-9 2041-1723 |
url |
https://repository.urosario.edu.co/handle/10336/20449 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationTitle.none.fl_str_mv |
Nature Communications |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 9 |
dc.relation.ispartof.spa.fl_str_mv |
Nature Communications, ISSN:2041-1723, Vol. 9 (2018) |
dc.relation.uri.spa.fl_str_mv |
https://www.nature.com/articles/s41467-018-04766-9 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
institution |
Universidad del Rosario |
dc.source.bibliographicCitation.spa.fl_str_mv |
Kannel, W.B., Benjamin, E.J., Current perceptions of the epidemiology of atrial fibrillation (2009) Cardiol. Clin., 27, pp. 13-24. , PID: 19111760 |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
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WouterKääb, StefanLehtimäki, TerhoLiu, YongmeiMunroe, Patricia B.Parsa, AfshinPolasek, OzrenPsaty, Bruce M.Roden, Dan M.Schnabel, Renate B.Sinagra, GianfrancoStefansson, KariStricker, Bruno H.van der Harst, Pimvan Duijn, Cornelia M.Wilson,James F.Gharib, Sina A.de Bakker, Paul I.W.Isaacs, AaronArking, Dan E.Sotoodehnia, Nona2019-10-17T12:55:20Z2019-10-17T12:55:20Z20182018Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are over-represented in cardiac disease processes including heart block and atrial fibrillation. Variants in over half of the 44 loci were associated with atrial or blood transcript expression levels, or were in high linkage disequilibrium with missense variants. Six additional loci were identified either by meta-analysis of ~105,000 African and European-descent individuals and/or by pleiotropic analyses combining PR interval with heart rate, QRS interval, and atrial fibrillation. These findings implicate developmental pathways, and identify transcription factors, ion-channel genes, and cell-junction/cell-signaling proteins in atrio-ventricular conduction, identifying potential targets for drug development. © 2018, The Author(s).application/pdf10.1038/s41467-018-04766-92041-1723https://repository.urosario.edu.co/handle/10336/20449engNature CommunicationsVol. 9Nature Communications, ISSN:2041-1723, Vol. 9 (2018)https://www.nature.com/articles/s41467-018-04766-9Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Kannel, W.B., Benjamin, E.J., Current perceptions of the epidemiology of atrial fibrillation (2009) Cardiol. Clin., 27, pp. 13-24. , PID: 19111760instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURIon ChannelTranscription FactorDisequilibriumGenetic AnalysisGenomeMeta-AnalysisRisk FactorAfricanAtrial FibrillationAtrioventricular ConductionCell JunctionElectric ActivityEuropeanGene Linkage DisequilibriumGene LocusGenome-Wide Association StudyHeart BlockHeart DepolarizationHeart RateHumanMissense MutationPhenotypePr IntervalQrs IntervalSignal TransductionCanal de ionesFactor de transcripciónSangreSistema cardiovascularEnfermedades616600Cardiovascular systemBloodHeart DiseaseArticleEnfermedades cardiovascularesFibrilación auricularBloqueo cardíacoPR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activityarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501van Setten, JessicaBrody, Jennifer A.Jamshidi, YaldaSwenson, Brenton R.Butler, Anne M.Campbell, HarryDel Greco, Fabiola M.Evans, Daniel S.Gibson, QuinceGudbjartsson, Daniel F.Kerr, KathleenKrijthe, Bouwe P.Lyytikäinen, Leo-PekkaMüller, ChristianMüller-Nurasyid, MartinaNolte, Ilja M.Padmanabhan, SandoshRitchie, Marylyn D.Robino, AntoniettaSmith, Albert V.Steri, MaristellaTanaka, ToshikoTeumer, AlexanderTrompet, StellaUlivi, SheilaVerweij, NiekYin, XiaoyanArnar, David O.Asselbergs, Folkert W.Bader, Joel S.Barnard, JohnBis, JoshBlankenberg, StefanBoerwinkle, EricBradford, YukiBuckley, Brendan M.Chung, Mina K.Crawford, Danaden Hoed, MarcelDenny, Josh C.Dominiczak, Anna F.Ehret, Georg B.Eijgelsheim, MarkEllinor, Patrick T.Felix, Stephan B.Franco, Oscar H.Franke, LudeHarris, Tamara B.Holm, HilmaGANDIN, ILARIAIorio, AnnamariaKähönen, MikaKolcic, IvanaKors, Jan A.Lakatta, Edward G.Launer, Lenore J.Lin, HonghuangLin, Henry J.Loos, Ruth J.F.Lubitz, Steven A.Macfarlane, Peter W.Magnani, Jared W.Mateo Leach, IreneMeitinger, ThomasMitchell, Braxton D.Munzel, ThomasPapanicolaou, George J.Peters, AnnettePfeufer, ArnePramstaller, Peter P.Raitakari, Olli T.Rotter, Jerome I.Rudan, IgorSamani, Nilesh J.Schlessinger, DavidSilva Aldana, Claudia T.Sinner, Moritz F.Smith, Jonathan D.Snieder, HaroldSoliman, Elsayed Z.Spector, Timothy D.Stott, David J.Strauch, KonstantinTarasov, Kirill V.Thorsteinsdottir, UnnurUitterlinden, Andre G.Van Wagoner, David R.Völker, UweVölzke, HenryWaldenberger, MelanieWestra, Harm JanWild, Philipp S.Zeller, TanjaAlonso, AlvaroAvery, Christy L.Bandinelli, StefaniaBenjamin, Emelia J.Cucca, FrancescoDörr, MarcusFerrucci, LuigiGasparini, PaoloORIGINAL9.pdfapplication/pdf2370431https://repository.urosario.edu.co/bitstreams/0ada85e2-8e62-456b-b091-097f0cbc3609/downloade8213d40cd6045670bfa1d708db82d84MD51TEXT9.pdf.txt9.pdf.txtExtracted texttext/plain81885https://repository.urosario.edu.co/bitstreams/e894ea83-cb08-4dbc-9e1f-d0cdce66fbed/download66eabe1e32de57ed49ef86e740dadcc6MD52THUMBNAIL9.pdf.jpg9.pdf.jpgGenerated Thumbnailimage/jpeg3303https://repository.urosario.edu.co/bitstreams/5d89c5fd-f515-4b92-a3a0-8ba530e1bad0/download640af909f5d8c764761068639f3843cbMD5310336/20449oai:repository.urosario.edu.co:10336/204492020-02-12 16:21:11.472https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |