CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms

Although host defense against human immunodeficiency virus 1 (HIV-1) relies mainly on cell-mediated immunity (CMI), the determinants of CMI in humans are poorly understood. Here we demonstrate that variations in the genes encoding the chemokine CCL3L1 and HIV coreceptor CCR5 influence CMI in both healthy and HIV-infected individuals. CCL3L1-CCR5 genotypes associated with altered CMI in healthy subjects were similar to those that influence the risk of HIV transmission, viral burden and disease progression. However, CCL3L1-CCR5 genotypes also modify HIV clinical course independently of their effects on viral load and CMI. These results identify CCL3L1 and CCR5 as major determinants of CMI and demonstrate that these host factors influence HIV pathogenesis through their effects on both CMI and other viral entry-independent mechanisms.

• Fecha de publicación: 2007
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/22641
• Acceso en línea: https://doi.org/10.1038/ni1521; https://repository.urosario.edu.co/handle/10336/22641
• Palabra clave: Chemokine receptor CCR5; Macrophage inflammatory protein 1alpha; Macrophage inflammatory protein 1alpha L1; Unclassified drug; Acquired immune deficiency syndrome; Animal experiment; Animal model; Article; Cellular immunity; Controlled study; Disease course; DNA modification; Genetic association; Genetic variability; Genotype; Host resistance; Human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; Infection risk; Mouse; Nonhuman; Pathogenesis; Priority journal; Virus load; Virus transmission; Virus virulence; Acquired Immunodeficiency Syndrome; Genotype; HIV Infections; HIV-1; Humans; Viral Load; Cellular; CC; CCR5; Chemokines; Immunity; Receptors
• License: Abierto (Texto Completo)