CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms

Although host defense against human immunodeficiency virus 1 (HIV-1) relies mainly on cell-mediated immunity (CMI), the determinants of CMI in humans are poorly understood. Here we demonstrate that variations in the genes encoding the chemokine CCL3L1 and HIV coreceptor CCR5 influence CMI in both he...

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Autores:

Tipo de recurso:

Fecha de publicación:

2007

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/22641

Acceso en línea:

https://doi.org/10.1038/ni1521
https://repository.urosario.edu.co/handle/10336/22641

Palabra clave:

Chemokine receptor CCR5
Macrophage inflammatory protein 1alpha
Macrophage inflammatory protein 1alpha L1
Unclassified drug
Acquired immune deficiency syndrome
Animal experiment
Animal model
Article
Cellular immunity
Controlled study
Disease course
DNA modification
Genetic association
Genetic variability
Genotype
Host resistance
Human
Human immunodeficiency virus 1
Human immunodeficiency virus infection
Infection risk
Mouse
Nonhuman
Pathogenesis
Priority journal
Virus load
Virus transmission
Virus virulence
Acquired Immunodeficiency Syndrome
Genotype
HIV Infections
HIV-1
Humans
Viral Load
Cellular
CC
CCR5
Chemokines
Immunity
Receptors

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