Copy number variation profiling in pharmacogenetics CYP-450 and GST genes in Colombian population

Background: Copy Number variation (CNVs) in genes related to drug absorption, distribution, metabolism and excretion (ADME) are relevant in the interindividual variability of drug response. Studies of the CNVs in ADME genes in Latin America population are lacking. The objective of the study was to i...

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Autores:

Tipo de recurso:

Fecha de publicación:

2019

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/23573

Acceso en línea:

https://doi.org/10.1186/s12920-019-0556-x
https://repository.urosario.edu.co/handle/10336/23573

Palabra clave:

Genomic DNA
Cytochrome P450
Glutathione transferase
Adult
Allele
Article
Cohort analysis
Colombian
Copy number variation
CYP-450 gene
CYP1A1 gene
CYP1A2 gene
CYP1B1 gene
CYP2A6 gene
CYP2B6 gene
CYP2C19 gene
CYP2C9 gene
CYP2D gene
CYP2E1 gene
CYP3A4 gene
CYP3A5 gene
DNA isolation
Female
Gene
Gene deletion
Gene duplication
Gene frequency
Genetic profile
Genetic variability
Genotype
GST gene
GSTM1 gene
GSTP1 gene
GSTT1 gene
Human
Male
Normal human
Personalized medicine
Pharmacogenetics
Priority journal
South and Central America
Colombia
Genetics
Colombia
Cytochrome P-450 Enzyme System
DNA Copy Number Variations
Gene Frequency
Genotype
Glutathione Transferase
Humans
Pharmacogenetics
Allele frequency
DNA copy number variation
Personalized medicine
DNA
Pharmacogenomics

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Abierto (Texto Completo)