Defects in the synthesis of ζ chain in T lymphocytes, generating wrong intracellular signals, responsible for systemic lupus erythematosus

The abnormal expression of key molecules in signaling and the malfunction of the T cell T have a significant activity in the pathogenesis of the autoimmune disease. The cells T exhibit numerous abnormalities in the signaling of the complex TCR1, these aberrations result in the alteration of the citoquines. While some of these abnormalities explain the increase of the activity of cells B for cells T with increment of the antibodies production, the decrease in the production of IL-2 induces an increase in the susceptibility to the infections, diminishing in the activation of the cells T, and expansion of the lifespan of the autorreactive cells2. © 2010 Asociación Colombiana de Reumatología

• Fecha de publicación: 2010
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: spa
• OAI Identifier: oai:repository.urosario.edu.co:10336/23068
• Acceso en línea: https://doi.org/10.1016/S0121-8123(10)70069-4; https://repository.urosario.edu.co/handle/10336/23068
• Palabra clave: Interleukin 2; T lymphocyte receptor; T lymphocyte receptor zeta chain; Unclassified drug; Antibody production; Autoimmune disease; Cell expansion; Cytokine production; Infection sensitivity; Intracellular signaling; Pathogenesis; Protein synthesis; Review; Systemic lupus erythematosus; T lymphocyte; T lymphocyte activation; Camkiv; Ctla-4; Elf-1; Fcγ; Itam; Les; Lupus; Tcrζ; Utr
• License: Abierto (Texto Completo)