Defects in the synthesis of ? chain in T lymphocytes, generating wrong intracellular signals, responsible for systemic lupus erythematosus

The abnormal expression of key molecules in signaling and the malfunction of the T cell T have a significant activity in the pathogenesis of the autoimmune disease. The cells T exhibit numerous abnormalities in the signaling of the complex TCR1, these aberrations result in the alteration of the cito...