Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice

We have developed monoclonal antibodies directed against the pseudopeptide ?-130, derived from the highly conserved malarial antigen Plasmodium falciparum merozoite surface protein 2 (MSP-2), for obtaining novel molecular tools with potential applications in the control of malaria. Following isotype...

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Autores:
Tipo de recurso:
Fecha de publicación:
2009
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/22784
Acceso en línea:
https://doi.org/10.1016/j.peptides.2008.10.022
https://repository.urosario.edu.co/handle/10336/22784
Palabra clave:
Immunoglobulin
Immunoglobulin class
Malaria vaccine
Merozoite surface protein 2
Monoclonal antibody
Monoclonal antibody anti pseudopeptide psi 130
Pseudopeptide
Unclassified drug
Animal cell
Animal experiment
Animal model
Animal tissue
Article
Controlled study
Drug design
Drug mechanism
Drug synthesis
Female
Mouse
Nonhuman
Parasitemia
Passive immunization
Plasmodium berghei infection
Plasmodium falciparum
Priority journal
Animals
Antibodies, protozoan
Antigens, protozoan
Disease models, animal
Female
Immunization, passive
Malaria
Mice
Mice, inbred balb c
Parasitemia
Plasmodium berghei
Plasmodium falciparum
Protozoan proteins
Recombinant proteins
Murinae
Mus
Plasmodium berghei
Plasmodium falciparum
Anti-malarial vaccine
Ig isotype
In vivo neutralizing activity
Murine malarial infection
Pseudopeptide
protozoan
Rights
License
Abierto (Texto Completo)
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spelling 2e90ff7c-f30e-4cb3-bb86-41916c1c72ae-10b3f2261-a522-4a91-ae3b-76200da750d0-12c1f11ba-edb4-4498-a3ef-6813708a8870-184cece1e-359c-45a6-b251-f8e4b62a84eb-1e5c1554a-8831-48b6-8d8d-b1deafd9840b-19e3ba9df-fe89-48fe-9521-cc8f452d56f5-1ed02648e-d655-4bbd-8d6e-90ad3efa4387-12020-05-25T23:58:00Z2020-05-25T23:58:00Z2009We have developed monoclonal antibodies directed against the pseudopeptide ?-130, derived from the highly conserved malarial antigen Plasmodium falciparum merozoite surface protein 2 (MSP-2), for obtaining novel molecular tools with potential applications in the control of malaria. Following isotype switching, these antibodies were tested for their ability to suppress blood-stage parasitemia through passive immunization in malaria-infected mice. Some proved totally effective in suppressing a lethal blood-stage challenge infection and others reduced malarial parasitemia. Protection against P. berghei malaria following Ig passive immunization can be associated with specific immunoglobulins induced by a site-directed designed MSP-2 reduced amide pseudopeptide. © 2008 Elsevier Inc. All rights reserved.application/pdfhttps://doi.org/10.1016/j.peptides.2008.10.0221969781https://repository.urosario.edu.co/handle/10336/22784eng342No. 2330PeptidesVol. 30Peptides, ISSN:1969781, Vol.30, No.2 (2009); pp. 330-342https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149484910&doi=10.1016%2fj.peptides.2008.10.022&partnerID=40&md5=e5477e7d371aea7c48e5732ae309ed1bAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURImmunoglobulinImmunoglobulin classMalaria vaccineMerozoite surface protein 2Monoclonal antibodyMonoclonal antibody anti pseudopeptide psi 130PseudopeptideUnclassified drugAnimal cellAnimal experimentAnimal modelAnimal tissueArticleControlled studyDrug designDrug mechanismDrug synthesisFemaleMouseNonhumanParasitemiaPassive immunizationPlasmodium berghei infectionPlasmodium falciparumPriority journalAnimalsAntibodies, protozoanAntigens, protozoanDisease models, animalFemaleImmunization, passiveMalariaMiceMice, inbred balb cParasitemiaPlasmodium bergheiPlasmodium falciparumProtozoan proteinsRecombinant proteinsMurinaeMusPlasmodium bergheiPlasmodium falciparumAnti-malarial vaccineIg isotypeIn vivo neutralizing activityMurine malarial infectionPseudopeptideprotozoanPassive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected micearticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Martínez, Paola A.Yandar, NubiaLesmes, Liliana P.Forero, MarthaPérez-Leal, OscarPatarroyo, Manuel ElkinLozano, José ManuelORIGINAL1-s2-0-S0196978108004531-main.pdfapplication/pdf1756259https://repository.urosario.edu.co/bitstreams/1e71b490-30bf-48d8-93b5-9387ea643425/download661f0cec2d7942e93243c3b812580ea8MD51TEXT1-s2-0-S0196978108004531-main.pdf.txt1-s2-0-S0196978108004531-main.pdf.txtExtracted texttext/plain59014https://repository.urosario.edu.co/bitstreams/61470ada-144f-4dd0-ad11-de6eaeeba0d0/download695fd81e22d255dc0150405d3c0260eeMD52THUMBNAIL1-s2-0-S0196978108004531-main.pdf.jpg1-s2-0-S0196978108004531-main.pdf.jpgGenerated Thumbnailimage/jpeg4659https://repository.urosario.edu.co/bitstreams/591cf151-ad16-494f-bb7e-46ddd0f4599d/download2c5be7095a115c8bb192ab9a11ad58a1MD5310336/22784oai:repository.urosario.edu.co:10336/227842021-06-03 00:51:37.738https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice
title Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice
spellingShingle Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice
Immunoglobulin
Immunoglobulin class
Malaria vaccine
Merozoite surface protein 2
Monoclonal antibody
Monoclonal antibody anti pseudopeptide psi 130
Pseudopeptide
Unclassified drug
Animal cell
Animal experiment
Animal model
Animal tissue
Article
Controlled study
Drug design
Drug mechanism
Drug synthesis
Female
Mouse
Nonhuman
Parasitemia
Passive immunization
Plasmodium berghei infection
Plasmodium falciparum
Priority journal
Animals
Antibodies, protozoan
Antigens, protozoan
Disease models, animal
Female
Immunization, passive
Malaria
Mice
Mice, inbred balb c
Parasitemia
Plasmodium berghei
Plasmodium falciparum
Protozoan proteins
Recombinant proteins
Murinae
Mus
Plasmodium berghei
Plasmodium falciparum
Anti-malarial vaccine
Ig isotype
In vivo neutralizing activity
Murine malarial infection
Pseudopeptide
protozoan
title_short Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice
title_full Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice
title_fullStr Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice
title_full_unstemmed Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice
title_sort Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice
dc.subject.keyword.spa.fl_str_mv Immunoglobulin
Immunoglobulin class
Malaria vaccine
Merozoite surface protein 2
Monoclonal antibody
Monoclonal antibody anti pseudopeptide psi 130
Pseudopeptide
Unclassified drug
Animal cell
Animal experiment
Animal model
Animal tissue
Article
Controlled study
Drug design
Drug mechanism
Drug synthesis
Female
Mouse
Nonhuman
Parasitemia
Passive immunization
Plasmodium berghei infection
Plasmodium falciparum
Priority journal
Animals
Antibodies, protozoan
Antigens, protozoan
Disease models, animal
Female
Immunization, passive
Malaria
Mice
Mice, inbred balb c
Parasitemia
Plasmodium berghei
Plasmodium falciparum
Protozoan proteins
Recombinant proteins
Murinae
Mus
Plasmodium berghei
Plasmodium falciparum
Anti-malarial vaccine
Ig isotype
In vivo neutralizing activity
Murine malarial infection
Pseudopeptide
topic Immunoglobulin
Immunoglobulin class
Malaria vaccine
Merozoite surface protein 2
Monoclonal antibody
Monoclonal antibody anti pseudopeptide psi 130
Pseudopeptide
Unclassified drug
Animal cell
Animal experiment
Animal model
Animal tissue
Article
Controlled study
Drug design
Drug mechanism
Drug synthesis
Female
Mouse
Nonhuman
Parasitemia
Passive immunization
Plasmodium berghei infection
Plasmodium falciparum
Priority journal
Animals
Antibodies, protozoan
Antigens, protozoan
Disease models, animal
Female
Immunization, passive
Malaria
Mice
Mice, inbred balb c
Parasitemia
Plasmodium berghei
Plasmodium falciparum
Protozoan proteins
Recombinant proteins
Murinae
Mus
Plasmodium berghei
Plasmodium falciparum
Anti-malarial vaccine
Ig isotype
In vivo neutralizing activity
Murine malarial infection
Pseudopeptide
protozoan
dc.subject.keyword.eng.fl_str_mv protozoan
description We have developed monoclonal antibodies directed against the pseudopeptide ?-130, derived from the highly conserved malarial antigen Plasmodium falciparum merozoite surface protein 2 (MSP-2), for obtaining novel molecular tools with potential applications in the control of malaria. Following isotype switching, these antibodies were tested for their ability to suppress blood-stage parasitemia through passive immunization in malaria-infected mice. Some proved totally effective in suppressing a lethal blood-stage challenge infection and others reduced malarial parasitemia. Protection against P. berghei malaria following Ig passive immunization can be associated with specific immunoglobulins induced by a site-directed designed MSP-2 reduced amide pseudopeptide. © 2008 Elsevier Inc. All rights reserved.
publishDate 2009
dc.date.created.spa.fl_str_mv 2009
dc.date.accessioned.none.fl_str_mv 2020-05-25T23:58:00Z
dc.date.available.none.fl_str_mv 2020-05-25T23:58:00Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.peptides.2008.10.022
dc.identifier.issn.none.fl_str_mv 1969781
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/22784
url https://doi.org/10.1016/j.peptides.2008.10.022
https://repository.urosario.edu.co/handle/10336/22784
identifier_str_mv 1969781
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 342
dc.relation.citationIssue.none.fl_str_mv No. 2
dc.relation.citationStartPage.none.fl_str_mv 330
dc.relation.citationTitle.none.fl_str_mv Peptides
dc.relation.citationVolume.none.fl_str_mv Vol. 30
dc.relation.ispartof.spa.fl_str_mv Peptides, ISSN:1969781, Vol.30, No.2 (2009); pp. 330-342
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149484910&doi=10.1016%2fj.peptides.2008.10.022&partnerID=40&md5=e5477e7d371aea7c48e5732ae309ed1b
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
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