STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians
The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population. This was a case-control study in which 839 indivi...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2008
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/24142
- Acceso en línea:
- https://doi.org/10.1038/gene.2008.30
https://repository.urosario.edu.co/handle/10336/24142
- Palabra clave:
- Complement component C5
STAT4 protein
Tumor necrosis factor receptor associated factor 1
Article
Autoimmunity
Case control study
Colombia
Controlled study
Genetic polymorphism
Genetic risk
Genetic susceptibility
Genotype
Human
Major clinical study
Mouse strain
Polymerase chain reaction
Priority journal
Protein variant
Rheumatoid arthritis
Risk factor
Systemic lupus erythematosus
Alleles
Case-Control Studies
Cohort Studies
Colombia
Gene Frequency
Genotype
Humans
Risk Factors
STAT4 Transcription Factor
TNF Receptor-Associated Factor 1
Variation (Genetics)
Rheumatoid
Single Nucleotide
Systemic
Arthritis
Lupus Erythematosus
Polymorphism
- Rights
- License
- Abierto (Texto Completo)
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8ca11cd5-7c84-49f1-a8a6-6be0848bfa538aa08ddc-3b0d-4a49-a320-6a8b48a80d50f75e2932-0719-472f-8117-a0a59f38616e63e48aec-07d1-4580-80df-4bffc08e2772194747786001bc1f7de-1e94-4d53-9526-b318eff1b2bb2020-05-26T00:09:10Z2020-05-26T00:09:10Z2008The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population. This was a case-control study in which 839 individuals with RA (N = 274) and SLE (N = 144) and matched healthy controls (N = 421) were included. Genotyping was performed by using a polymerase chain reaction system with pre-developed TaqMan allelic discrimination assay. STAT4 rs7574865T allele disclosed a significant influence on the risk of developing SLE (P = 0.0005; OR 1.62, 95% CI 1.22-2.16) and RA (P = 0.008; OR 1.36; 95% CI 1.08-1.71), whereas no effect on these autoimmune diseases was observed for the TRAF1/C5 polymorphisms examined. Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases.application/pdfhttps://doi.org/10.1038/gene.2008.301466487914765470https://repository.urosario.edu.co/handle/10336/24142eng382No. 4379Genes and ImmunityVol. 9Genes and Immunity, ISSN:14664879, 14765470, Vol.9, No.4 (2008); pp. 379-382https://www.scopus.com/inward/record.uri?eid=2-s2.0-44849140782&doi=10.1038%2fgene.2008.30&partnerID=40&md5=653c2cbcb21cbd32c5d5b47282c17e0bAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURComplement component C5STAT4 proteinTumor necrosis factor receptor associated factor 1ArticleAutoimmunityCase control studyColombiaControlled studyGenetic polymorphismGenetic riskGenetic susceptibilityGenotypeHumanMajor clinical studyMouse strainPolymerase chain reactionPriority journalProtein variantRheumatoid arthritisRisk factorSystemic lupus erythematosusAllelesCase-Control StudiesCohort StudiesColombiaGene FrequencyGenotypeHumansRisk FactorsSTAT4 Transcription FactorTNF Receptor-Associated Factor 1Variation (Genetics)RheumatoidSingle NucleotideSystemicArthritisLupus ErythematosusPolymorphismSTAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in ColombiansarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Palomino-Morales, R JRojas-Villarraga, AGonzález, C IRamírez, GAnaya, Juan-ManuelMartín, JORIGINALgene200830.pdfapplication/pdf120776https://repository.urosario.edu.co/bitstreams/620ab369-2545-4668-a055-c75a2fe145c9/downloade708e42b966d7114452864f858f9b870MD51TEXTgene200830.pdf.txtgene200830.pdf.txtExtracted texttext/plain20068https://repository.urosario.edu.co/bitstreams/faca37c4-9746-4115-8dc0-e8830faeff6f/download11929a823269b98256ad6afd362be15eMD52THUMBNAILgene200830.pdf.jpggene200830.pdf.jpgGenerated Thumbnailimage/jpeg5307https://repository.urosario.edu.co/bitstreams/a1bd9b27-2fdd-4235-a459-11a6ea0f3b04/downloadf183a1b98fe763b2cfcb85e20e32937cMD5310336/24142oai:repository.urosario.edu.co:10336/241422022-05-02 07:37:13.490805https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians |
title |
STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians |
spellingShingle |
STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians Complement component C5 STAT4 protein Tumor necrosis factor receptor associated factor 1 Article Autoimmunity Case control study Colombia Controlled study Genetic polymorphism Genetic risk Genetic susceptibility Genotype Human Major clinical study Mouse strain Polymerase chain reaction Priority journal Protein variant Rheumatoid arthritis Risk factor Systemic lupus erythematosus Alleles Case-Control Studies Cohort Studies Colombia Gene Frequency Genotype Humans Risk Factors STAT4 Transcription Factor TNF Receptor-Associated Factor 1 Variation (Genetics) Rheumatoid Single Nucleotide Systemic Arthritis Lupus Erythematosus Polymorphism |
title_short |
STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians |
title_full |
STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians |
title_fullStr |
STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians |
title_full_unstemmed |
STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians |
title_sort |
STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians |
dc.subject.keyword.spa.fl_str_mv |
Complement component C5 STAT4 protein Tumor necrosis factor receptor associated factor 1 Article Autoimmunity Case control study Colombia Controlled study Genetic polymorphism Genetic risk Genetic susceptibility Genotype Human Major clinical study Mouse strain Polymerase chain reaction Priority journal Protein variant Rheumatoid arthritis Risk factor Systemic lupus erythematosus Alleles Case-Control Studies Cohort Studies Colombia Gene Frequency Genotype Humans Risk Factors STAT4 Transcription Factor TNF Receptor-Associated Factor 1 Variation (Genetics) |
topic |
Complement component C5 STAT4 protein Tumor necrosis factor receptor associated factor 1 Article Autoimmunity Case control study Colombia Controlled study Genetic polymorphism Genetic risk Genetic susceptibility Genotype Human Major clinical study Mouse strain Polymerase chain reaction Priority journal Protein variant Rheumatoid arthritis Risk factor Systemic lupus erythematosus Alleles Case-Control Studies Cohort Studies Colombia Gene Frequency Genotype Humans Risk Factors STAT4 Transcription Factor TNF Receptor-Associated Factor 1 Variation (Genetics) Rheumatoid Single Nucleotide Systemic Arthritis Lupus Erythematosus Polymorphism |
dc.subject.keyword.eng.fl_str_mv |
Rheumatoid Single Nucleotide Systemic Arthritis Lupus Erythematosus Polymorphism |
description |
The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population. This was a case-control study in which 839 individuals with RA (N = 274) and SLE (N = 144) and matched healthy controls (N = 421) were included. Genotyping was performed by using a polymerase chain reaction system with pre-developed TaqMan allelic discrimination assay. STAT4 rs7574865T allele disclosed a significant influence on the risk of developing SLE (P = 0.0005; OR 1.62, 95% CI 1.22-2.16) and RA (P = 0.008; OR 1.36; 95% CI 1.08-1.71), whereas no effect on these autoimmune diseases was observed for the TRAF1/C5 polymorphisms examined. Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases. |
publishDate |
2008 |
dc.date.created.spa.fl_str_mv |
2008 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:09:10Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:09:10Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1038/gene.2008.30 |
dc.identifier.issn.none.fl_str_mv |
14664879 14765470 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/24142 |
url |
https://doi.org/10.1038/gene.2008.30 https://repository.urosario.edu.co/handle/10336/24142 |
identifier_str_mv |
14664879 14765470 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
382 |
dc.relation.citationIssue.none.fl_str_mv |
No. 4 |
dc.relation.citationStartPage.none.fl_str_mv |
379 |
dc.relation.citationTitle.none.fl_str_mv |
Genes and Immunity |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 9 |
dc.relation.ispartof.spa.fl_str_mv |
Genes and Immunity, ISSN:14664879, 14765470, Vol.9, No.4 (2008); pp. 379-382 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-44849140782&doi=10.1038%2fgene.2008.30&partnerID=40&md5=653c2cbcb21cbd32c5d5b47282c17e0b |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
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Abierto (Texto Completo) |
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application/pdf |
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