STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians

The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population. This was a case-control study in which 839 individuals with RA (N = 274) and SLE (N = 144) and matched healthy controls (N = 421) were included. Genotyping was performed by using a polymerase chain reaction system with pre-developed TaqMan allelic discrimination assay. STAT4 rs7574865T allele disclosed a significant influence on the risk of developing SLE (P = 0.0005; OR 1.62, 95% CI 1.22-2.16) and RA (P = 0.008; OR 1.36; 95% CI 1.08-1.71), whereas no effect on these autoimmune diseases was observed for the TRAF1/C5 polymorphisms examined. Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases.

• Fecha de publicación: 2008
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/24142
• Acceso en línea: https://doi.org/10.1038/gene.2008.30; https://repository.urosario.edu.co/handle/10336/24142
• Palabra clave: Complement component C5; STAT4 protein; Tumor necrosis factor receptor associated factor 1; Article; Autoimmunity; Case control study; Colombia; Controlled study; Genetic polymorphism; Genetic risk; Genetic susceptibility; Genotype; Human; Major clinical study; Mouse strain; Polymerase chain reaction; Priority journal; Protein variant; Rheumatoid arthritis; Risk factor; Systemic lupus erythematosus; Alleles; Case-Control Studies; Cohort Studies; Colombia; Gene Frequency; Genotype; Humans; Risk Factors; STAT4 Transcription Factor; TNF Receptor-Associated Factor 1; Variation (Genetics); Rheumatoid; Single Nucleotide; Systemic; Arthritis; Lupus Erythematosus; Polymorphism
• License: Abierto (Texto Completo)