Glucosylceramides from Lomentospora prolificans induce a differential production of cytokines and increases the microbicidal activity of macrophages

Lomentospora prolificans is an emerging opportunistic fungus with a high resistance to antifungal agents and it can cause localized infections in immunocompetent patients and disseminated infections with a high mortality rate in immunosuppressed patients. Glucosylceramides (GlcCer) are synthetized i...

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Autores:
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24092
Acceso en línea:
https://doi.org/10.3389/fmicb.2019.00554
https://repository.urosario.edu.co/handle/10336/24092
Palabra clave:
CXCL2 chemokine
Gamma interferon
Glucosylceramide
Interleukin 10
Interleukin 17
Superoxide
Tumor necrosis factor
Animal experiment
Animal model
Antigen recognition
Antioxidant activity
Article
Carbohydrate analysis
Cellular distribution
Cytokine production
Electrospray mass spectrometry
Enzyme linked immunosorbent assay
Female
Fungus growth
High performance thin layer chromatography
Immune response
Immunocompetence
Immunocompromised patient
Immunodetection
Immunofluorescence
Immunohistochemistry
Immunoreactivity
Macrophage
Microbicidal activity
Mortality rate
Mouse
Nonhuman
Pathogenicity
Phagocytosis
Respiratory burst
Glccer
Glucosylceramides
Innate immune response
Lomentospora prolificans
Structural characterization
Rights
License
Abierto (Texto Completo)