T-Cell-specific loss of the PI-3-linase p110? catalytic subunit results in enhanced cytokine production and antitumor response

Class IA phosphatidylinositol 3-kinase (PI3K) catalytic subunits p110? and p110? are targets in cancer therapy expressed at high levels in T lymphocytes. The role of p110? PI3K in normal or pathological immune responses is well established, yet the importance of p110? subunits in T cell-dependent im...