Gauche+ side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccine

Topological and stereo-electron characteristics are essential in major histocompability class II-peptide-T-cell receptor (MHC-p-TCR) complex formation for inducing an appropriate immune response. Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalar...

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Autores:

Tipo de recurso:

Fecha de publicación:

2014

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/23461

Acceso en línea:

https://doi.org/10.1016/j.vaccine.2014.02.003
https://repository.urosario.edu.co/handle/10336/23461

Palabra clave:

protozoan
immunologic
falciparum
Adjuvants
Antibodies
Malaria
Malaria vaccine
Peptide vaccine
Unclassified drug
Very high long lasting antibody inducing modified high activity binding peptide
Animal experiment
Antibody production
Antibody titer
Aotus
Article
Controlled study
Drug mixture
Enzyme linked immunosorbent assay
Gauche side chain orientation
Genotype
Immune response
Immunofluorescence
Immunogenicity
Nonhuman
Priority journal
Protection
Protein structure
Proton nuclear magnetic resonance
Sporozoite
Vaccination
Western blotting
Antimalarial vaccine
Gauche(+)
Peptide mixtures
Protective immunity
?(1) angle
Amino acid sequence
Animals
Antibody formation
Aotus trivirgatus
Binding sites
Hla-dr beta-chains
Malaria vaccines
Molecular sequence data
Oligopeptides
Protein conformation
Antimalarial vaccine
Peptide mixtures
Protective immunity

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