Peripheral mitochondrial function correlates with clinical severity in idiopathic Parkinson’s disease
Background: Parkinson’s disease is an intractable disorder with heterogeneous clinical presentation that may reflect different underlying pathogenic mechanisms. Surrogate indicators of pathogenic processes correlating with clinical measures may assist in better patient stratification. Mitochondrial...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2019
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/22631
- Acceso en línea:
- https://doi.org/10.1002/mds.27723
https://repository.urosario.edu.co/handle/10336/22631
- Palabra clave:
- Alpha synuclein
Galactose
Glucose
Levodopa
Rotenone
Aged
Article
Biochemical analysis
Bioenergy
Bivariate analysis
Cell function
Clinical article
Clinical feature
Correlation analysis
Cross-sectional study
Disease severity
Energy yield
Female
Glycolysis
Human
Idiopathic disease
In vitro study
Machine learning
Male
Metabolic stress
Mitochondrial respiration
Mitochondrion
Oxidative phosphorylation
Parkinson disease
Pathogenesis
Priority journal
Protein phosphorylation
Respirometry
Aerobic metabolism
Clinical outcome
Disease duration
Disease severity
Fibroblast
Human cell
Idiopathic disease
Molecular pathology
Oxygen consumption
Parkinson disease
Sh-sy5y cell line
Synucleinopathy
Unified parkinson disease rating scale
Upregulation
Clinical phenotyping
Mitochondria
Parkinson’s disease
?-synuclein
- Rights
- License
- Abierto (Texto Completo)