Infections and vaccines in the etiology of antiphospholipid syndrome

Purpose of review: To present scientific evidence supporting the infectious origin for the antiphospholipid syndrome (APS) by molecular mimicry between pathogens, infection and vaccination with ?2-glycoprotein I (?2-GPI) molecule. Recent findings: APS is characterized by the presence of pathogenic autoantibodies against ?2-GPI. The infection etiology of APS was well established. Likewise, a link between vaccination such as tetanus toxoid may trigger antibodies targeting tetanus toxoid and ?2-GPI, due to molecular mimicry between the two molecules. During the years, the pathogenic potential of anti-tetanus toxoid antibodies cross reactive with ?2-GPI were found to be pathogenic in animal models, inducing experimental APS. Summary: Accumulated evidence supports that the presence of anti-?2-GPI antibodies is associated with a history of infections and the main mechanism to explain this correlation is molecular mimicry. The relationship between tetanus toxoid vaccination and APS reveals a novel view on the autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA). © 2012 Wolters Kluwer Health

• Fecha de publicación: 2012
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23823
• Acceso en línea: https://doi.org/10.1097/BOR.0b013e32835448b8; https://repository.urosario.edu.co/handle/10336/23823
• Palabra clave: 4 aminobutyric acid; Aluminum hydroxide; Beta2 glycoprotein 1; Beta2 glycoprotein 1 antibody; Cardiolipin antibody; Diphtheria antibody; Ganglioside antibody; Glycerol; Immunoglobulin a antibody; Immunoglobulin g antibody; Immunoglobulin m antibody; Interleukin 1 receptor; Laminin; Myeloid differentiation factor 88; Tetanus toxoid; Toll like receptor; Antibody production; Antiphospholipid syndrome; Autoinflammatory disease; Blood clotting time; Clostridium tetani; Cross reaction; Enzyme linked immunosorbent assay; Fetus wastage; Human; Infection; Medical history; Molecular mimicry; Nonhuman; Partial thromboplastin time; Priority journal; Review; Signal transduction; Tetanus prophylaxis; Thrombocytopenia; Antiphospholipid syndrome; Autoantibodies; Beta 2-glycoprotein i; Cross reactions; Humans; Infection; Molecular mimicry; Tetanus toxoid; ?2-glycoprotein i; Antiphospholipid syndrome; Tetanus toxoid; immunologic; Adjuvants
• License: Abierto (Texto Completo)