Anti-group A streptococcal vaccine epitope : Structure, stability, and its ability to interact with HLA class II molecules

Streptococcus pyogenes infections remain a health problem in several countries due to poststreptococcal sequelae. We developed a vaccine epitope (StreptInCor) composed of 55 amino acids residues of the C-terminal portion of the M protein that encompasses both T and B cell protective epitopes. The nu...

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Autores:

Tipo de recurso:

Fecha de publicación:

2011

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/21890

Acceso en línea:

https://doi.org/10.1074/jbc.M110.132118
https://repository.urosario.edu.co/handle/10336/21890

Palabra clave:

Ciencias médicas, Medicina
Química & ciencias afines
controlled study
human
Biomolecular
B-Lymphocyte
Secondary
Tertiary
T-Lymphocyte
Humans
Amino acid sequence
B cells
Class II
Helical structures
Helix residues
Humoral immune response
Micro-domains
Microdomain
Potential sites
Streptococcus pyogenes
T-cell epitopes
Terminal portions
UV circular dichroism
Amino acids
Chemical stability
Dichroism
Molecules
Nuclear magnetic resonance
Peptides
Resonance
Urea
Vaccines
Antigens
Amino acid
Epitope
HLA antigen class 2
HLA DR antigen
M protein
Peptide
Streptincor
Streptococcus vaccine
Unclassified drug
Urea
Alpha helix
Alpha helix
Amino acid sequence
Antigen binding
Antigen recognition
Article
Carboxy terminal sequence
Cellular immunity
Circular dichroism
Human tissue
Humoral immunity
Molecular interaction
Molecular stability
Nuclear magnetic resonance
pH
Prediction
Priority journal
Protein domain
Protein folding
Protein structure
Streptococcus pyogenes
Antigen Presentation
Epitopes
Epitopes
Histocompatibility Antigens Class II
Nuclear Magnetic Resonance
Protein Stability
Protein Structure
Protein Structure
Streptococcal Infections
Streptococcal Vaccines
Streptococcus pyogenes

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