Oxidative Stress Promotes Doxorubicin-Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions

P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) are ATP binding cassette (ABC) transporters that are overexpressed in different drug-resistant cancer cell lines. In this study, we investigated whether doxorubicin promotes Pgp and/or BCRP expression to induce drug resistance in colon...

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Autores:

Tipo de recurso:

Fecha de publicación:

2017

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/22281

Acceso en línea:

https://doi.org/10.1002/jcb.25890
https://repository.urosario.edu.co/handle/10336/22281

Palabra clave:

Breast cancer resistance protein
Cobalt chloride
Doxorubicin
E 3330
Hypoxia inducible factor 1alpha
Lyase inhibitor
Multidrug resistance protein
Reactive oxygen metabolite
Unclassified drug
Breast cancer resistance protein
Dna (apurinic or apyrimidinic site) lyase
Doxorubicin
Hypoxia inducible factor 1alpha
Multidrug resistance protein 1
Tumor protein
Article
Cancer growth
Cancer resistance
Cancer survival
Colon cancer
Confocal microscopy
Controlled study
Enzyme linked immunosorbent assay
Ht-29 cell line
Human
Human cell
Hypoxia
Oxidative stress
Priority journal
Protein expression
Reverse transcription polymerase chain reaction
Cell hypoxia
Cell survival
Colon tumor
Drug effects
Genetics
Ht-29 cell line
Metabolism
Oxidative stress
Physiology
Tumor cell line
Cell hypoxia
Cell survival
Colonic neoplasms
Dna-(apurinic or apyrimidinic site) lyase
Doxorubicin
Enzyme-linked immunosorbent assay
Ht29 cells
Humans
Neoplasm proteins
Oxidative stress
Reactive oxygen species
Colon cancer
Drug resistance
P-glycoprotein
Reactive oxygen species
confocal
tumor
human
human
human
alpha subunit
sub-family g
sub-family b
member 1
member 2
Abcg2 protein
Apex1 protein
Hif1a protein
Atp binding cassette transporter
Atp-binding cassette
Cell line
Hypoxia-inducible factor 1
Microscopy

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