Identification of conserved erythrocyte binding regions in members of the Plasmodium falciparum Cys6 lipid raft-associated protein family

Detergent-resistant lipid raft membrane-associated Pf12, Pf38 and Pf41 proteins belong to the Cys6 family, whose members are implicated in Plasmodium falciparum invasion to erythrocytes. We have analyzed the interaction between 20-mer-long synthetic peptides spanning the entire Pf12, Pf38 and Pf41 s...

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Autores:

Tipo de recurso:

Fecha de publicación:

2009

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/23451

Acceso en línea:

https://doi.org/10.1016/j.vaccine.2009.04.039
https://repository.urosario.edu.co/handle/10336/23451

Palabra clave:

Alanylglycyllysylvalylasparaginylasparaginyllysylvalyl cysteinyllysylisoleucylglutaminylglycyllysylprolylglycylglutamyll eucylvalylglycine
Alanylleucylasparaginylarginylphenylalanyllysyllysyl methionyllysylaspartylleucylseryllysylphenylalanylphenylalanyl asparaginylaspartylglutaminylalanylaspartic acid
Asparaginylthreonylthreonyllysylleucylasparaginylleucyl prolyllysylserylleucylasparaginylisoleucylprolylasparaginylaspartyl isoleucylleucylasparaginyltyrosinel
Cysteine derivative
Leucylhistidyllysylasparaginyllysylvalylthreonylaspartyll eucyllysylthreonylleucylisoleucylprolylglycyltyrosylalanylseryltyrosylthreonine
Malaria vaccine
Membrane protein
Methionylaspartylhistidyltyrosylasparaginylasparaginyl threonylphenylalanyltyrosylserylarginylleucylprolylserylleucyl isoleucylserylaspartylasparaginyltryptophan
Peptide derivative
Pf12 protein
Pf38 protein
Pf41 protein
Tyrosylserylisoleucyllysylprolylaspartylglycylcysteinylphenyl alanylserylasparaginylvalyltyrosylvalyllysylarginyltyrosylprolyl asparaginylglutamine
Unclassified drug
Valylisoleucylglycylserylserylmethionylphenylalanylmethionyl arginylarginylserylleucylthreonylprolylasparaginyllysylisoleucyl asparaginylglutamylvaline
Valylleucylarginylisoleucylhistidylisoleucylserylasparaginyl glycylvalylleucylarginyllysylisoleucylprolylglycylcysteinyl aspartylphenylalanylasparagine
Alpha helix
Article
Beta turn
Binding affinity
Binding site
Erythrocyte
Host parasite interaction
Human
Human cell
Lipid raft
Malaria
Merozoite
Plasmodium falciparum
Priority journal
Protein analysis
Protein function
Animals
Erythrocytes
Humans
Plasmodium falciparum
Protein binding
Protein interaction mapping
Protozoan proteins
Antimalarial vaccine
Cys6 family
High-activity binding peptides
Pf12
Pf38
Pf41
Plasmodium falciparum
tertiary
secondary
protozoan
cell surface
Antigens
Protein structure
Protein structure
Receptors

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