Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA

Objectives Systemic lupus erythematosus (SLE; OMIM 152700) is characterised by the production of antibodies to nuclear antigens. We previously identified variants in complement receptor 2 (CR2/CD21) that were associated with decreased risk of SLE. This study aimed to identify the causal variant for...

Full description

Autores:

Tipo de recurso:

Fecha de publicación:

2016

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/22444

Acceso en línea:

https://doi.org/10.1136/annrheumdis-2014-205584
https://repository.urosario.edu.co/handle/10336/22444

Palabra clave:

Complement component C3b receptor
Complement receptor
Complement receptor 2
Double stranded DNA antibody
Messenger RNA
Transcription factor CTCF
Unclassified drug
Antinuclear antibody
Complement component C3b receptor
Complement component C3d receptor
CR1 protein, human
DNA
Transcription factor
Allele
Article
B lymphocyte
Case control study
Chromatin immunoprecipitation
Controlled study
DNA protein complex
Flow cytometry
Gel mobility shift assay
Genetic association
Genetic variability
Genotype
Human
Intron
Major clinical study
Pathogenesis
Priority journal
Real time polymerase chain reaction
Systemic lupus erythematosus
Adolescent
Adult
Biosynthesis
Blood
Genetic predisposition
Genetic variation
Genetics
Haplotype
Immunology
Metabolism
Middle aged
Phenotype
Procedures
Risk assessment
Single nucleotide polymorphism
Systemic lupus erythematosus
Young adult
Adolescent
Adult
B-Lymphocyte Subsets
Case-Control Studies
DNA
Genetic Predisposition to Disease
Genetic Variation
Genotype
Haplotypes
Humans
Middle Aged
Phenotype
Receptors, Complement 3d
Risk Assessment
Transcription Factors
Young Adult
Systemic
Antinuclear
Single Nucleotide
Antibodies
Lupus Erythematosus
Polymorphism

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