Lupus risk variant increases pSTAT1 binding and decreases ETS1 expression

Genetic variants at chromosomal region 11q23.3, near the gene ETS1, have been associated with systemic lupus erythematosus (SLE), or lupus, in independent cohorts of Asian ancestry. Several recent studies have implicated ETS1 as a critical driver of immune cell function and differentiation, and mice...

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Autores:

Tipo de recurso:

Fecha de publicación:

2015

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/24141

Acceso en línea:

https://doi.org/10.1016/j.ajhg.2015.03.002
https://repository.urosario.edu.co/handle/10336/24141

Palabra clave:

Dna
Microrna
Stat1 protein
Transcription factor
Transcription factor ets 1
Protein binding
Stat1 protein
Transcription factor ets 1
Allele
Article
Asian
Autoimmunity
B lymphocyte
Bayesian learning
Chromatin
Chromatin immunoprecipitation
Gene locus
Gene mapping
Genetic model
Genetic risk
Genetic variability
Genotype
Han chinese
Human
Immunoblotting
Mass spectrometry
Model
Priority journal
Protein binding
Systemic lupus erythematosus
Animal
Asian continental ancestry group
Bayes theorem
Genetic predisposition
Genetics
Haplotype
Metabolism
Mouse
Systemic lupus erythematosus
Mus
Alleles
Animals
Asian continental ancestry group
Bayes theorem
Genetic predisposition to disease
Genotype
Haplotypes
Humans
Mice
Protein binding
Proto-oncogene protein c-ets-1
Stat1 transcription factor
systemic
human
Ets1 protein
Lupus erythematosus

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