BMP15 c.-9C>G promoter sequence variant may contribute to the cause of non-syndromic premature ovarian failure

BMP15 has drawn particular attention in the pathophysiology of reproduction, as its mutations in mammalian species have been related to different reproductive phenotypes. In humans, BMP15 coding regions have been sequenced in large panels of women with premature ovarian failure (POF), but only some...

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Autores:

Tipo de recurso:

Fecha de publicación:

2014

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/22924

Acceso en línea:

https://doi.org/10.1016/j.rbmo.2014.07.018
https://repository.urosario.edu.co/handle/10336/22924

Palabra clave:

Bone morphogenetic protein 15
Transcription factor
Transcription factor pitx1
Unclassified drug
Bone morphogenetic protein 15
Homeobox protein pitx1
Luciferase
Paired box transcription factor
Adult
Allele
Animal tissue
Article
Binding site
Bioinformatics
Computer model
Controlled study
Female
Gene expression profiling
Genetic association
Human
Human cell
In vitro study
Luciferase assay
Mouse
Nonhuman
Nucleotide sequence
Pathogenesis
Premature ovarian failure
Promoter region
Protein binding
Reverse transcription polymerase chain reaction
Single nucleotide polymorphism
Transactivation
Animal
Biology
Chlorocebus aethiops
Cos 1 cell line
Genetic transcription
Genetic variability
Genetics
Metabolism
Mutation
Ovary
Phenotype
Premature ovarian failure
Transcription initiation
Alleles
Animals
Binding sites
Bone morphogenetic protein 15
Cercopithecus aethiops
Computational biology
Cos cells
Female
Genetic variation
Humans
Luciferases
Mice
Mutation
Ovary
Paired box transcription factors
Phenotype
Primary ovarian insufficiency
Transcriptional activation
Bioinformatics
Bmp15
Female infertility
Pitx1
Premature ovarian failure
single nucleotide
genetic
genetic
human
Bmp15 protein
Polymorphism
Promoter regions
Transcription

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