Temporal gene expression in the hippocampus and peripheral organs to endotoxin-induced systemic inflammatory response in caspase-1-deficient mice

Objectives: Caspase-1 (casp1), a key protease involved in the systemic inflammatory response syndrome (SIRS), controls the brain expression of a set of eight genes: Nos2 and Ptgs2 (nitric oxide synthase 2 and prostaglandin-endoperoxide synthase 2, two inducible enzymes), Cxcl1 and Cxcl10 (C-X-C moti...

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Autores:

Tipo de recurso:

Fecha de publicación:

2015

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/22651

Acceso en línea:

https://doi.org/10.1159/000368310
https://repository.urosario.edu.co/handle/10336/22651

Palabra clave:

Endotoxin
Escherichia coli lipopolysaccharide
Sodium chloride
Interleukin 1beta converting enzyme
Lipopolysaccharide
Adamts1 gene
Adrenal gland
Animal experiment
Animal model
Animal tissue
Article
Caspase 1 gene
Controlled study
Correlation coefficient
Cxc motif ligand 1 gene
Cxc motif ligand 10 gene
Disintegrin like and metallopeptidase with thrombospondin type 1 motif 1 gene
Gene expression profiling
Gene inactivation
Gene interaction
Genetic association
Guanylate binding protein 2 gene
Hippocampus
Immune response gene
Immunogenetics
Inducible nitric oxide synthase gene
Inflammation
Injection
Interleukin 1 receptor antagonist gene
Lethality
Male
Mouse
Nerve cell plasticity
Nonhuman
Priority journal
Prostaglandin endoperoxide synthase 2 gene
Real time polymerase chain reaction
Spleen
Systemic inflammatory response syndrome
T cell specific gtpase 1 gene
Wild type
Adrenal gland
Animal
C57bl mouse
Chemically induced
Deficiency
Disease model
Gene expression
Genetics
Hippocampus
Knockout mouse
Metabolism
Spleen
Systemic inflammatory response syndrome
Adrenal glands
Animals
Caspase 1
Gene expression
Hippocampus
Lipopolysaccharides
Male
Mice
Spleen
Systemic inflammatory response syndrome
Adamts1
Chemokines
Coexpression
Cox2
Cxcl1
Cxcl10
Inflammation
Lipopolysaccharide
Nos2
Transcription
animal
knockout
inbred c57bl
Disease models
Mice
Mice

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