TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus

Background and aim: The involvement of Toll-like receptor (TLR)-mediated pathways in infectious and autoimmunity has been suggested. The MyD88 adaptor-like (Mal) protein, also known as the TIR domain-containing adaptor protein (TIRAP), is implicated in the TLR2- and TLR4-mediated MyD88-dependent signaling pathway. The aim of this study was to investigate the influence of the functional TIRAP (MAL) S180L polymorphism on tuberculosis (TB) and four autoimmune diseases namely: rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1D). Methods: This was a case-control and family based association study in which 1325 individuals from a well-defined Colombian population were involved. TIRAP (MAL) S180L genotyping was done by using a polymerase chain reaction-restriction fragment length polymorphism technique and by direct sequencing. Results: Leu180 allele was found to be a protective factor against developing TB (odd ratio (OR): 0.53, 95% confidence interval (CI): 0.29-0.97) and SLE (OR: 0.29, 95% CI: 0.14-0.61) while no significant influence on RA, pSS and T1D was observed. Conclusion: These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response. © 2008 Elsevier B.V. All rights reserved.

• Fecha de publicación: 2008
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/24308
• Acceso en línea: https://doi.org/10.1016/j.meegid.2008.03.001; https://repository.urosario.edu.co/handle/10336/24308
• Palabra clave: Adaptor protein; Leucine; Toll like receptor domain containing adaptor protein; Adult; Allele; Article; Autoimmune disease; Case control study; Colombia; Confidence interval; Controlled study; Family; Female; Gene sequence; Genetic polymorphism; Genetic susceptibility; Genotype; Human; Innate immunity; Insulin dependent diabetes mellitus; Major clinical study; Male; Polymerase chain reaction; Priority journal; Protection; Restriction fragment length polymorphism; Rheumatoid arthritis; Sjoegren syndrome; Systemic lupus erythematosus; Tuberculosis; Adult; Case-control studies; Colombia; Female; Gene frequency; Genotype; Humans; Male; Membrane glycoproteins; Middle aged; Tuberculosis; Mal; Rheumatoid arthritis; Sjögren's syndrome; Systemic lupus erythematosus; Tirap; Tuberculosis; Type 1 diabetes mellitus; systemic; interleukin-1; genetic; Lupus erythematosus; Polymorphism; Receptors
• License: Abierto (Texto Completo)