Transcriptional regulator PRDM12 is essential for human pain perception

Pain perception has evolved as a warning mechanism to alert organisms to tissue damage and dangerous environments. In humans, however, undesirable, excessive or chronic pain is a common and major societal burden for which available medical treatments are currently suboptimal. New therapeutic options...

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Autores:

Tipo de recurso:

Fecha de publicación:

2015

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/22640

Acceso en línea:

https://doi.org/10.1038/ng.3308
https://repository.urosario.edu.co/handle/10336/22640

Palabra clave:

Isoprotein
Prdm12 protein
Unclassified drug
Carrier protein
Nerve protein
Animal cell
Article
Autonomic innervation
Basement membrane
Cell nucleus
Cellular distribution
Chromosome 9
Chronic pain
Codon
Congenital analgesia
Cornea reflex
Cytoplasm
Differentiation
Embryo
Embryo development
Heterozygote
Histone methylation
Histone modification
Human
In situ hybridization
Missense mutation
Nervous system development
Neural crest cell
Nociception
Nonhuman
Pain receptor
Phenotype
Point mutation
Priority journal
Protein expression
Protein function
Protein interaction
Sensory nerve cell
Sodium current
Sural nerve
Tissue injury
Xenopus
Animal
Chlorocebus aethiops
Consanguinity
Cos 1 cell line
Female
Genetic association
Genetics
Male
Metabolism
Mutation
Neuropathy
Pedigree
Single nucleotide polymorphism
Xenopus laevis
Animals
Carrier proteins
Cercopithecus aethiops
Consanguinity
Cos cells
Female
Genetic association studies
Hereditary sensory and autonomic neuropathies
Humans
Male
Mutation
Nerve tissue proteins
Neurogenesis
Nociceptors
Pain perception
Pedigree
Xenopus laevis
human
single nucleotide
congenital
Prdm12 protein
Pain insensitivity
Polymorphism

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