A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus

Systemic lupus erythematosus (SLE or lupus) (OMIM: 152700) is a chronic autoimmune disease with debilitating inflammation that affects multiple organ systems. The STAT1-STAT4 locus is one of the first and most highly replicated genetic loci associated with lupus risk. We performed a fine-mapping stu...

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Autores:

Tipo de recurso:

Fecha de publicación:

2018

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/24225

Acceso en línea:

https://doi.org/10.1093/hmg/ddy140
https://repository.urosario.edu.co/handle/10336/24225

Palabra clave:

High mobility group A protein
HMGA1 protein
STAT1 protein
STAT4 protein
Unclassified drug
STAT1 protein
STAT4 protein
Allele
Article
B-lymphocyte cell line
Controlled study
DNA binding
Expression quantitative trait locus
Functional disease
Gene locus
Genetic variability
Human
Intron
Lupus vulgaris
Priority journal
Protein domain
Protein expression
Allele
Clinical trial
Female
Genetic polymorphism
Genetics
Male
Multicenter study
Quantitative trait locus
Risk factor
Systemic lupus erythematosus
Alleles
Female
Humans
Male
Quantitative Trait Loci
Risk Factors
STAT1 Transcription Factor
STAT4 Transcription Factor
Systemic
Genetic
human
human
STAT1 protein
STAT4 protein
Lupus Erythematosus
Polymorphism

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