A Sequence in Subdomain 2 of DBL1? of Plasmodium falciparum Erythrocyte Membrane Protein 1 Induces Strain Transcending Antibodies

Immunity to severe malaria is the first level of immunity acquired to Plasmodium falciparum. Antibodies to the variant antigen PfEMP1 (P. falciparum erythrocyte membrane protein 1) present at the surface of the parasitized red blood cell (pRBC) confer protection by blocking microvascular sequestrati...

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Autores:

Tipo de recurso:

Fecha de publicación:

2013

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/22840

Acceso en línea:

https://doi.org/10.1371/journal.pone.0052679
https://repository.urosario.edu.co/handle/10336/22840

Palabra clave:

Erythrocyte membrane protein 1
Protein antibody
Strain transcending antibody
Unclassified drug
Amino acid sequence
Antigen antibody reaction
Antigen binding
Article
Child
Disease severity
Erythrocyte
Female
Flow cytometry
Human
Immunofluorescence test
In vitro study
Malaria
Male
Nonhuman
Plasmodium falciparum
Preschool child
Protein binding
Protein domain
Protein motif
Amino acid motifs
Amino acid sequence
Animals
Antibody specificity
Cross reactions
Epitopes
Erythrocytes
Female
Humans
Immunoglobulin g
Infant
Male
Molecular sequence data
Peptides
Plasmodium falciparum
Protein binding
Protein conformation
Protein interaction domains and motifs
Protozoan proteins
Rabbits
Rats
Plasmodium falciparum
molecular
protozoan
protozoan
preschool
Antibodies
Antigens
Child
Models

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Abierto (Texto Completo)