Creating and validating a warfarin pharmacogenetic dosing algorithm for colombian patients

Purpose: Warfarin is an oral anticoagulant associated with adverse reaction to drugs due to wide inter-and intra-individual dosage variability. Warfarin dosage has been related to non-genetic and genetic factors. CYP2C9 and VKORC1 gene polymorphisms affect warfarin metabolism and dosage. Due to the...

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Autores:

Tipo de recurso:

Fecha de publicación:

2018

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/22796

Acceso en línea:

https://doi.org/10.2147/PGPM.S170515
https://repository.urosario.edu.co/handle/10336/22796

Palabra clave:

Alanine
Cysteine
Cytochrome p450 2c9
Glycine
Threonine
Warfarin
Adult
Aged
Algorithm
Amino acid substitution
Article
Cohort analysis
Colombian
Controlled study
Cyp2c9 gene
Cyp4f2 gene
Female
Gene
Genetic polymorphism
Genetic variability
Genotype
Human
Maintenance drug dose
Major clinical study
Male
Multiple linear regression analysis
Pharmacogenetics
Thromboembolism
Very elderly
Vkorc1 gene
Adverse drug reaction
Anticoagulants
Gene frequency
Genetic polymorphism

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