Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population

Fetal hemoglobin (HbF) is a determining factor for the development of sickle cell anemia. High HbF levels lower the intensity of symptoms of this disease. HbF levels can vary in patients with sickle cell anemia and individuals without the disease.

Autores:
Fong Reales, Cristian javier
Mendoza Y.
Barreto G.
Tipo de recurso:
Article of journal
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/51025
Acceso en línea:
https://doi.org/10.1590/1678-4685-gmb-2019-0076
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083893639&doi=10.1590%2f1678-4685-gmb-2019-0076&partnerID=40&md5=5561adcca39ee670ec62d132e370bb4a
https://hdl.handle.net/20.500.12494/51025
Palabra clave:
ARTICLE
COLOMBIAN
CHROMOSOME
G GAMMA GLOBIN GENE
GENE
GENE FREQUENCY
GENETIC VARIABILITY
HEMOGLOBIN F
HUMAN
MAJOR CLINICAL STUDY
MULTICENTER STUDY
PROMOTER REGION
PROTEIN EXPRESSION
SICKLE CELL ANEMIA
SINGLE NUCLEOTIDE POLYMORPHISM
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2