Quantitative profiling of the UGT transcriptome in human drug-metabolizing tissues.

Alternative splicing as a mean to control gene expression and diversify function is suspected to considerably influence drug response and clearance. We report the quantitative expression profiles of the human UGT genes including alternatively spliced variants not previously annotated established by...

Full description

Autores:

Tourancheau A
Rouleau M
Guauque Olarte, Sandra milena
Villeneuve L
Gilbert I
Droit A
Guillemette C

Tipo de recurso:

Article of journal

Fecha de publicación:

2023

Institución:

Universidad Cooperativa de Colombia

Repositorio:

Repositorio UCC

Idioma:

OAI Identifier:

oai:repository.ucc.edu.co:20.500.12494/50266

Acceso en línea:

https://doi.org/10.1038/tpj.2017.5
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046073558&doi=10.1038%2ftpj.2017.5&partnerID=40&md5=e81a249eafd5030d4af5d88884bf09c7
https://hdl.handle.net/20.500.12494/50266

Palabra clave:

ALTERNATIVE RNA SPLICING
ARTICLE
CARCINOGENESIS
CONTROLLED STUDY
DRUG
DRUG CLEARANCE
DRUG EFFECT
DRUG METABOLISM
DRUG RESPONSE
FEMALE
GENE
GENE EXPRESSION PROFILING
GENE EXPRESSION REGULATION
GENETIC VARIABILITY
GENETICS
GLUCURONOSYLTRANSFERASE
HUMAN
HUMAN TISSUE
HUMANS
INTERINDIVIDUAL VARIABILITY
MALE
METABOLIC CLEARANCE RATE
METABOLISM
PHARMACEUTICAL PREPARATIONS
PHARMACOGENETIC VARIANT
PHARMACOGENOMIC VARIANTS
PHYSIOLOGY
PRIORITY JOURNAL
PROCEDURES
PROTEOME
RNA SEQUENCE
TISSUE DISTRIBUTION
TRANSCRIPTOME
UGT GENE
UGT1 GENE
UGT1A1 ENZYME
UGT2 GENE
UGT2A1 PROTEIN, HUMAN

Rights

openAccess

License

http://purl.org/coar/access_right/c_abf2