Human macrophages differentiated in the presence of vitamin D3 restrict dengue virus infection and innate responses by downregulating mannose receptor expression.

During the last decades, there has been an expansion in the geographic range and incidence of dengue virus (DENV) due to spreading of its mosquito vectors, globalization and the lack of a protective tetravalent dengue vaccine. It is estimated that nearly a third of the world population is at risk of...