Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population

Fetal hemoglobin (HbF) is a determining factor for the development of sickle cell anemia. High HbF levels lower the intensity of symptoms of this disease. HbF levels can vary in patients with sickle cell anemia and individuals without the disease.

Autores:
Fong Reales, Cristian Javier
Mendoza Y.
Barreto G.
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/42307
Acceso en línea:
https://doi.org/10.3303/CET1649065
https://hdl.handle.net/20.500.12494/42307
Palabra clave:
hemoglobin F
Article
chromosome
Colombian
G gamma globin gene
gene
gene frequency
genetic variability
human
major clinical study
multicenter study
promoter region
protein expression
sickle cell anemia
single nucleotide polymorphism
Rights
closedAccess
License
http://purl.org/coar/access_right/c_14cb
id COOPER2_c96829dd90ad1761051d8a9421eb9592
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/42307
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Fong Reales, Cristian JavierMendoza Y.Barreto G.2021-12-16T22:16:10Z2021-12-16T22:16:10Z2020https://doi.org/10.3303/CET164906514154757https://hdl.handle.net/20.500.12494/42307Fong C,Mendoza Y,Barreto G. Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population. Genet Mol Biol. 2020. 43. (2):p. 1-7. .Fetal hemoglobin (HbF) is a determining factor for the development of sickle cell anemia. High HbF levels lower the intensity of symptoms of this disease. HbF levels can vary in patients with sickle cell anemia and individuals without the disease.0000-0003-1864-2186cristian.fongr@campusucc.edu.co7-1Brazilian Journal of Geneticshemoglobin FArticlechromosomeColombianG gamma globin genegenegene frequencygenetic variabilityhumanmajor clinical studymulticenter studypromoter regionprotein expressionsickle cell anemiasingle nucleotide polymorphismGenetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian populationArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionGenetics And Molecular Biologyinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/42307oai:repository.ucc.edu.co:20.500.12494/423072024-08-20 16:23:23.249metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population
title Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population
spellingShingle Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population
hemoglobin F
Article
chromosome
Colombian
G gamma globin gene
gene
gene frequency
genetic variability
human
major clinical study
multicenter study
promoter region
protein expression
sickle cell anemia
single nucleotide polymorphism
title_short Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population
title_full Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population
title_fullStr Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population
title_full_unstemmed Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population
title_sort Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population
dc.creator.fl_str_mv Fong Reales, Cristian Javier
Mendoza Y.
Barreto G.
dc.contributor.author.none.fl_str_mv Fong Reales, Cristian Javier
Mendoza Y.
Barreto G.
dc.subject.spa.fl_str_mv hemoglobin F
Article
chromosome
Colombian
G gamma globin gene
gene
gene frequency
genetic variability
human
major clinical study
multicenter study
promoter region
protein expression
sickle cell anemia
single nucleotide polymorphism
topic hemoglobin F
Article
chromosome
Colombian
G gamma globin gene
gene
gene frequency
genetic variability
human
major clinical study
multicenter study
promoter region
protein expression
sickle cell anemia
single nucleotide polymorphism
description Fetal hemoglobin (HbF) is a determining factor for the development of sickle cell anemia. High HbF levels lower the intensity of symptoms of this disease. HbF levels can vary in patients with sickle cell anemia and individuals without the disease.
publishDate 2020
dc.date.issued.none.fl_str_mv 2020
dc.date.accessioned.none.fl_str_mv 2021-12-16T22:16:10Z
dc.date.available.none.fl_str_mv 2021-12-16T22:16:10Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3303/CET1649065
dc.identifier.issn.spa.fl_str_mv 14154757
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/42307
dc.identifier.bibliographicCitation.spa.fl_str_mv Fong C,Mendoza Y,Barreto G. Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population. Genet Mol Biol. 2020. 43. (2):p. 1-7. .
url https://doi.org/10.3303/CET1649065
https://hdl.handle.net/20.500.12494/42307
identifier_str_mv 14154757
Fong C,Mendoza Y,Barreto G. Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population. Genet Mol Biol. 2020. 43. (2):p. 1-7. .
dc.relation.ispartofjournal.spa.fl_str_mv Genetics And Molecular Biology
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/closedAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_14cb
eu_rights_str_mv closedAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_14cb
dc.format.extent.spa.fl_str_mv 7-1
dc.publisher.spa.fl_str_mv Brazilian Journal of Genetics
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
_version_ 1814247340718948352

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