Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population
Fetal hemoglobin (HbF) is a determining factor for the development of sickle cell anemia. High HbF levels lower the intensity of symptoms of this disease. HbF levels can vary in patients with sickle cell anemia and individuals without the disease.
- Autores:
-
Fong Reales, Cristian Javier
Mendoza Y.
Barreto G.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/42307
- Palabra clave:
- hemoglobin F
Article
chromosome
Colombian
G gamma globin gene
gene
gene frequency
genetic variability
human
major clinical study
multicenter study
promoter region
protein expression
sickle cell anemia
single nucleotide polymorphism
- Rights
- closedAccess
- License
- http://purl.org/coar/access_right/c_14cb