Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population

Fetal hemoglobin (HbF) is a determining factor for the development of sickle cell anemia. High HbF levels lower the intensity of symptoms of this disease. HbF levels can vary in patients with sickle cell anemia and individuals without the disease.

• Autores: Fong Reales, Cristian Javier; Mendoza Y.; Barreto G.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2020
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/42307
• Acceso en línea: https://doi.org/10.3303/CET1649065; https://hdl.handle.net/20.500.12494/42307
• Palabra clave: hemoglobin F; Article; chromosome; Colombian; G gamma globin gene; gene; gene frequency; genetic variability; human; major clinical study; multicenter study; promoter region; protein expression; sickle cell anemia; single nucleotide polymorphism
• Rights: closedAccess
• License: http://purl.org/coar/access_right/c_14cb