In vitro and in vivo evaluation of 2-aminoalkanol and 1,2-alkanediamine derivatives against Strongyloides venezuelensis

Background: Strongyloidiasis is a parasitic disease widely present in tropical and subtropical areas. Strongyloides stercoralis represents the main species that infects human beings. Ivermectin is the current drug of choice; however, issues related with treatment failure in patients with diabetes or...

Full description

Autores:

Legarda-Ceballos A.L.
López-Abán J.
Del Olmo E.
Escarcena R.
Bustos L.A.
Rojas Caraballo, Jose Vicente
Vicente B.
Fernández-Soto P.
San Feliciano A.
Muro A.

Tipo de recurso:

Article of journal

Fecha de publicación:

2016

Institución:

Universidad Cooperativa de Colombia

Repositorio:

Repositorio UCC

Idioma:

OAI Identifier:

oai:repository.ucc.edu.co:20.500.12494/41843

Acceso en línea:

https://doi.org/10.16967/rpe.v4n2a3
http://revia.areandina.edu.co/ojs/index.php/IA/article/view/646
https://hdl.handle.net/20.500.12494/41843

Palabra clave:

1,2 alkanediamine derivative
2 aminoalkanol
antinematodal agent
edelfosine
ivermectin
unclassified drug
[2 (butylamino)hexadecan 1 ol]
[2 (ethylamino)hexadecan 1 ol]
[tert butyl n (1 aminododecan 2 yl)carbamate]
[tert butyl n (1 aminohexadecan 2 yl)carbamate]
aminoalcohol
anthelmintic agent
diamine
animal cell
animal experiment
animal model
animal tissue
Article
controlled study
cytotoxicity test
drug efficacy
drug identification
drug screening
drug structure
feces analysis
female
in vitro study
in vivo study
LC50
male
mouse
nonhuman
outcome assessment
rat
Strongyloides venezuelensis
strongyloidiasis
structure activity relation
XTT assay
animal
chemical structure
chemistry
drug effects
parasitology
Strongyloides
Amino Alcohols
Animals
Anthelmintics
Diamines
Male
Mice
Molecular Structure
Rats
Strongyloides
Strongyloidiasis
Structure-Activity Relationship

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License

http://purl.org/coar/access_right/c_14cb