Quantitative profiling of the UGT transcriptome in human drug-metabolizing tissues.

Alternative splicing as a mean to control gene expression and diversify function is suspected to considerably influence drug response and clearance. We report the quantitative expression profiles of the human UGT genes including alternatively spliced variants not previously annotated established by...

Full description

Autores:

Tourancheau, A
Rouleau, M
Guauque Olarte, Sandra Milena
Villeneuve, L
Gilbert, I
Droit, A
Guillemette, C

Tipo de recurso:

Article of journal

Fecha de publicación:

2018

Institución:

Universidad Cooperativa de Colombia

Repositorio:

Repositorio UCC

Idioma:

OAI Identifier:

oai:repository.ucc.edu.co:20.500.12494/41678

Acceso en línea:

https://doi.org/10.14349/rlp.2019.v51.n3.1
https://hdl.handle.net/20.500.12494/41678

Palabra clave:

glucuronosyltransferase
proteome
transcriptome
drug
glucuronosyltransferase
transcriptome
UGT1A1 enzyme
UGT2A1 protein
human
alternative RNA splicing
Article
carcinogenesis
controlled study
drug clearance
drug metabolism
drug response
female
gene
gene expression profiling
gene expression regulation
genetic variability
human
human tissue
interindividual variability
male
priority journal
RNA sequence
UGT gene
UGT1 gene
UGT2 gene
drug effect
genetics
metabolic clearance rate
metabolism
pharmacogenetic variant
physiology
procedures
tissue distribution
Gene Expression Profiling
Glucuronosyltransferase
Humans
Metabolic Clearance Rate
Pharmaceutical Preparations
Pharmacogenomic Variants
Tissue Distribution
Transcriptome

Rights

closedAccess

License

http://purl.org/coar/access_right/c_14cb