The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death

Strongyloidiasis is widely distributed in the tropical and subtropical areas. Ivermectin is the drug of choice for the treatment. However, the concerns about relying treatment on a single drug make identification of new molecules a priority. Alkylphospholipid analogues, including edelfosine, are a g...

Full description

Autores:
Legarda-Ceballos A.L.
Rojas Caraballo, Jose vicente
López-Abán J.
Ruano A.L.
Yepes E.
Gajate C.
Mollinedo F.
Muro A.
Tipo de recurso:
Article of journal
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/49637
Acceso en línea:
https://doi.org/10.1016/j.actatropica.2016.07.001
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978287632&doi=10.1016%2fj.actatropica.2016.07.001&partnerID=40&md5=8e8ad4042cf9c2f659d6a24b1bec33bc
https://hdl.handle.net/20.500.12494/49637
Palabra clave:
ANALOGS AND DERIVATIVES
ANIMAL
ANIMAL CELL
ANIMAL EXPERIMENT
ANIMAL MODEL
ANIMALS
ANTINEOPLASTIC AGENT
ANTINEOPLASTIC AGENTS
ANTIPROTOZOAL ACTIVITY
APOPTOSIS
ARTICLE
CELL COUNT
DNA
DNA FRAGMENTATION
DOSE RESPONSE
DOSE-RESPONSE RELATIONSHIP, DRUG
DRUG
DRUG CYTOTOXICITY
DRUG EFFECTS
DRUG EFFICACY
DRUG RESPONSE
DRUG STRUCTURE
DRUG TOLERABILITY
EDELFOSINE
ENDOTHELIUM CELL
ETHER PHOSPHOLIPID
FEMALE
FIBROBLAST
FRAGMENTATION
IC50
IN VITRO STUDY
IN VIVO STUDY
IVERMECTIN
LARVA
LD50
LIVER CELL
MICE
MILTEFOSINE
MOUSE
MUS
NEMATODE
NONHUMAN
PARASITE
PARASITOLOGY
PERIFOSINE
PHOSPHOLIPID
PHOSPHOLIPID ETHERS
PHOSPHORYLCHOLINE
STRONGYLOIDES
STRONGYLOIDES VENEZUELENSIS
STRONGYLOIDIASIS
TREATMENT DURATION
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2
id COOPER2_a7e0615884c269bbc641c722481b7f1f
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/49637
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Legarda-Ceballos A.L.Rojas Caraballo, Jose vicenteLópez-Abán J.Ruano A.L.Yepes E.Gajate C.Mollinedo F.Muro A.2023-05-24T16:21:35Z2023-05-24T16:21:35Z01/01/2016https://doi.org/10.1016/j.actatropica.2016.07.001https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978287632&doi=10.1016%2fj.actatropica.2016.07.001&partnerID=40&md5=8e8ad4042cf9c2f659d6a24b1bec33bc0001706Xhttps://hdl.handle.net/20.500.12494/49637Legarda-Ceballos A.L.,Rojas Caraballo Jose vicente,López-Abán J.,Ruano A.L.,Yepes E.,Gajate C.,Mollinedo F.,Muro A..The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death.ACTA TROP. 2016. 162.:p. 180-187Strongyloidiasis is widely distributed in the tropical and subtropical areas. Ivermectin is the drug of choice for the treatment. However, the concerns about relying treatment on a single drug make identification of new molecules a priority. Alkylphospholipid analogues, including edelfosine, are a group of synthetic compounds that have shown activity against some parasites. The objective was to assess the in vitro and in vivo activity of edelfosine, miltefosine, perifosine against Strongyloides venezuelensis. Moreover, apoptosis-like mechanism in larvae after treatment was studied. Edelfosine displayed the highest activity and the best selectivity index (LD50 = 49.6 ± 5.4 µM, SI = 1.1) compared to miltefosine or perifosine. Third stage larvae after culture with edelfosine were not able to develop an infection in mice. Treatment of mice with edelfosine showed reduction of 47% in parasitic females allocated in the gut. Moreover, DNA fragmentation was observed by TUNEL staining in larvae treated with edelfosine. These results suggest that edelfosine could be an effective drug against strongyloidiasis, probably through induction of apoptosis-like cell death. © 2016 Elsevier B.V.josev.rojas@campusucc.edu.co180-187ElsevierANALOGS AND DERIVATIVESANIMALANIMAL CELLANIMAL EXPERIMENTANIMAL MODELANIMALSANTINEOPLASTIC AGENTANTINEOPLASTIC AGENTSANTIPROTOZOAL ACTIVITYAPOPTOSISARTICLECELL COUNTDNADNA FRAGMENTATIONDOSE RESPONSEDOSE-RESPONSE RELATIONSHIP, DRUGDRUGDRUG CYTOTOXICITYDRUG EFFECTSDRUG EFFICACYDRUG RESPONSEDRUG STRUCTUREDRUG TOLERABILITYEDELFOSINEENDOTHELIUM CELLETHER PHOSPHOLIPIDFEMALEFIBROBLASTFRAGMENTATIONIC50IN VITRO STUDYIN VIVO STUDYIVERMECTINLARVALD50LIVER CELLMICEMILTEFOSINEMOUSEMUSNEMATODENONHUMANPARASITEPARASITOLOGYPERIFOSINEPHOSPHOLIPIDPHOSPHOLIPID ETHERSPHOSPHORYLCHOLINESTRONGYLOIDESSTRONGYLOIDES VENEZUELENSISSTRONGYLOIDIASISTREATMENT DURATIONThe alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell deathArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionACTA TROPinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/49637oai:repository.ucc.edu.co:20.500.12494/496372024-08-20 16:21:00.559metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
title The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
spellingShingle The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
ANALOGS AND DERIVATIVES
ANIMAL
ANIMAL CELL
ANIMAL EXPERIMENT
ANIMAL MODEL
ANIMALS
ANTINEOPLASTIC AGENT
ANTINEOPLASTIC AGENTS
ANTIPROTOZOAL ACTIVITY
APOPTOSIS
ARTICLE
CELL COUNT
DNA
DNA FRAGMENTATION
DOSE RESPONSE
DOSE-RESPONSE RELATIONSHIP, DRUG
DRUG
DRUG CYTOTOXICITY
DRUG EFFECTS
DRUG EFFICACY
DRUG RESPONSE
DRUG STRUCTURE
DRUG TOLERABILITY
EDELFOSINE
ENDOTHELIUM CELL
ETHER PHOSPHOLIPID
FEMALE
FIBROBLAST
FRAGMENTATION
IC50
IN VITRO STUDY
IN VIVO STUDY
IVERMECTIN
LARVA
LD50
LIVER CELL
MICE
MILTEFOSINE
MOUSE
MUS
NEMATODE
NONHUMAN
PARASITE
PARASITOLOGY
PERIFOSINE
PHOSPHOLIPID
PHOSPHOLIPID ETHERS
PHOSPHORYLCHOLINE
STRONGYLOIDES
STRONGYLOIDES VENEZUELENSIS
STRONGYLOIDIASIS
TREATMENT DURATION
title_short The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
title_full The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
title_fullStr The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
title_full_unstemmed The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
title_sort The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
dc.creator.fl_str_mv Legarda-Ceballos A.L.
Rojas Caraballo, Jose vicente
López-Abán J.
Ruano A.L.
Yepes E.
Gajate C.
Mollinedo F.
Muro A.
dc.contributor.author.none.fl_str_mv Legarda-Ceballos A.L.
Rojas Caraballo, Jose vicente
López-Abán J.
Ruano A.L.
Yepes E.
Gajate C.
Mollinedo F.
Muro A.
dc.subject.spa.fl_str_mv ANALOGS AND DERIVATIVES
ANIMAL
ANIMAL CELL
ANIMAL EXPERIMENT
ANIMAL MODEL
ANIMALS
ANTINEOPLASTIC AGENT
ANTINEOPLASTIC AGENTS
ANTIPROTOZOAL ACTIVITY
APOPTOSIS
ARTICLE
CELL COUNT
DNA
DNA FRAGMENTATION
DOSE RESPONSE
DOSE-RESPONSE RELATIONSHIP, DRUG
DRUG
DRUG CYTOTOXICITY
DRUG EFFECTS
DRUG EFFICACY
DRUG RESPONSE
DRUG STRUCTURE
DRUG TOLERABILITY
EDELFOSINE
ENDOTHELIUM CELL
ETHER PHOSPHOLIPID
FEMALE
FIBROBLAST
FRAGMENTATION
IC50
IN VITRO STUDY
IN VIVO STUDY
IVERMECTIN
LARVA
LD50
LIVER CELL
MICE
MILTEFOSINE
MOUSE
MUS
NEMATODE
NONHUMAN
PARASITE
PARASITOLOGY
PERIFOSINE
PHOSPHOLIPID
PHOSPHOLIPID ETHERS
PHOSPHORYLCHOLINE
STRONGYLOIDES
STRONGYLOIDES VENEZUELENSIS
STRONGYLOIDIASIS
TREATMENT DURATION
topic ANALOGS AND DERIVATIVES
ANIMAL
ANIMAL CELL
ANIMAL EXPERIMENT
ANIMAL MODEL
ANIMALS
ANTINEOPLASTIC AGENT
ANTINEOPLASTIC AGENTS
ANTIPROTOZOAL ACTIVITY
APOPTOSIS
ARTICLE
CELL COUNT
DNA
DNA FRAGMENTATION
DOSE RESPONSE
DOSE-RESPONSE RELATIONSHIP, DRUG
DRUG
DRUG CYTOTOXICITY
DRUG EFFECTS
DRUG EFFICACY
DRUG RESPONSE
DRUG STRUCTURE
DRUG TOLERABILITY
EDELFOSINE
ENDOTHELIUM CELL
ETHER PHOSPHOLIPID
FEMALE
FIBROBLAST
FRAGMENTATION
IC50
IN VITRO STUDY
IN VIVO STUDY
IVERMECTIN
LARVA
LD50
LIVER CELL
MICE
MILTEFOSINE
MOUSE
MUS
NEMATODE
NONHUMAN
PARASITE
PARASITOLOGY
PERIFOSINE
PHOSPHOLIPID
PHOSPHOLIPID ETHERS
PHOSPHORYLCHOLINE
STRONGYLOIDES
STRONGYLOIDES VENEZUELENSIS
STRONGYLOIDIASIS
TREATMENT DURATION
description Strongyloidiasis is widely distributed in the tropical and subtropical areas. Ivermectin is the drug of choice for the treatment. However, the concerns about relying treatment on a single drug make identification of new molecules a priority. Alkylphospholipid analogues, including edelfosine, are a group of synthetic compounds that have shown activity against some parasites. The objective was to assess the in vitro and in vivo activity of edelfosine, miltefosine, perifosine against Strongyloides venezuelensis. Moreover, apoptosis-like mechanism in larvae after treatment was studied. Edelfosine displayed the highest activity and the best selectivity index (LD50 = 49.6 ± 5.4 µM, SI = 1.1) compared to miltefosine or perifosine. Third stage larvae after culture with edelfosine were not able to develop an infection in mice. Treatment of mice with edelfosine showed reduction of 47% in parasitic females allocated in the gut. Moreover, DNA fragmentation was observed by TUNEL staining in larvae treated with edelfosine. These results suggest that edelfosine could be an effective drug against strongyloidiasis, probably through induction of apoptosis-like cell death. © 2016 Elsevier B.V.
publishDate 2023
dc.date.issued.none.fl_str_mv 01/01/2016
dc.date.accessioned.none.fl_str_mv 2023-05-24T16:21:35Z
dc.date.available.none.fl_str_mv 2023-05-24T16:21:35Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.actatropica.2016.07.001
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978287632&doi=10.1016%2fj.actatropica.2016.07.001&partnerID=40&md5=8e8ad4042cf9c2f659d6a24b1bec33bc
dc.identifier.issn.spa.fl_str_mv 0001706X
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/49637
dc.identifier.bibliographicCitation.spa.fl_str_mv Legarda-Ceballos A.L.,Rojas Caraballo Jose vicente,López-Abán J.,Ruano A.L.,Yepes E.,Gajate C.,Mollinedo F.,Muro A..The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death.ACTA TROP. 2016. 162.:p. 180-187
url https://doi.org/10.1016/j.actatropica.2016.07.001
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978287632&doi=10.1016%2fj.actatropica.2016.07.001&partnerID=40&md5=8e8ad4042cf9c2f659d6a24b1bec33bc
https://hdl.handle.net/20.500.12494/49637
identifier_str_mv 0001706X
Legarda-Ceballos A.L.,Rojas Caraballo Jose vicente,López-Abán J.,Ruano A.L.,Yepes E.,Gajate C.,Mollinedo F.,Muro A..The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death.ACTA TROP. 2016. 162.:p. 180-187
dc.relation.ispartofjournal.spa.fl_str_mv ACTA TROP
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 180-187
dc.publisher.spa.fl_str_mv Elsevier
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
_version_ 1814247105993113600

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