The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death

Strongyloidiasis is widely distributed in the tropical and subtropical areas. Ivermectin is the drug of choice for the treatment. However, the concerns about relying treatment on a single drug make identification of new molecules a priority. Alkylphospholipid analogues, including edelfosine, are a g...

Full description

Autores:

Legarda-Ceballos A.L.
Rojas Caraballo, Jose vicente
López-Abán J.
Ruano A.L.
Yepes E.
Gajate C.
Mollinedo F.
Muro A.

Tipo de recurso:

Article of journal

Fecha de publicación:

2023

Institución:

Universidad Cooperativa de Colombia

Repositorio:

Repositorio UCC

Idioma:

OAI Identifier:

oai:repository.ucc.edu.co:20.500.12494/49637

Acceso en línea:

https://doi.org/10.1016/j.actatropica.2016.07.001
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978287632&doi=10.1016%2fj.actatropica.2016.07.001&partnerID=40&md5=8e8ad4042cf9c2f659d6a24b1bec33bc
https://hdl.handle.net/20.500.12494/49637

Palabra clave:

ANALOGS AND DERIVATIVES
ANIMAL
ANIMAL CELL
ANIMAL EXPERIMENT
ANIMAL MODEL
ANIMALS
ANTINEOPLASTIC AGENT
ANTINEOPLASTIC AGENTS
ANTIPROTOZOAL ACTIVITY
APOPTOSIS
ARTICLE
CELL COUNT
DNA
DNA FRAGMENTATION
DOSE RESPONSE
DOSE-RESPONSE RELATIONSHIP, DRUG
DRUG
DRUG CYTOTOXICITY
DRUG EFFECTS
DRUG EFFICACY
DRUG RESPONSE
DRUG STRUCTURE
DRUG TOLERABILITY
EDELFOSINE
ENDOTHELIUM CELL
ETHER PHOSPHOLIPID
FEMALE
FIBROBLAST
FRAGMENTATION
IC50
IN VITRO STUDY
IN VIVO STUDY
IVERMECTIN
LARVA
LD50
LIVER CELL
MICE
MILTEFOSINE
MOUSE
MUS
NEMATODE
NONHUMAN
PARASITE
PARASITOLOGY
PERIFOSINE
PHOSPHOLIPID
PHOSPHOLIPID ETHERS
PHOSPHORYLCHOLINE
STRONGYLOIDES
STRONGYLOIDES VENEZUELENSIS
STRONGYLOIDIASIS
TREATMENT DURATION

Rights

openAccess

License

http://purl.org/coar/access_right/c_abf2