High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner

The common gamma (?c)-chain cytokine interleukin 15 (IL15) is a multifunctional immune-modulator which impacts the generation, maturation and activity of many cell types of the innate, as well as the adaptive immune system, including natural killer (NK) and CD8+ T cells. Using a new series of transg...

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Autores:: Polansky J.K.
Bahri R.
Divivier M.
Duitman E.H.
Vock C.
Goyeneche Patiño, Diego Andres
Orinska Z.
Bulfone-Paus S.

Tipo de recurso:: Article of journal

Fecha de publicación:: 2016

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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network_acronym_str	COOPER2
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repository_id_str
spelling	Polansky J.K.Bahri R.Divivier M.Duitman E.H.Vock C.Goyeneche Patiño, Diego AndresOrinska Z.Bulfone-Paus S.2021-12-16T22:15:42Z2021-12-16T22:15:42Z2016https://doi.org/10.14295/bds.2020.v23i3.2055https://hemeroteca.unad.edu.co/index.php/riaa/article/view/206720452322https://hdl.handle.net/20.500.12494/41677Polansky JK,Bahri R,Divivier M,Duitman EH,Vock C,Goyeneche DA,Orinska Z,Bulfone S. High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner. Sci Rep. 2016. 6. p. 19699-19699. .The common gamma (?c)-chain cytokine interleukin 15 (IL15) is a multifunctional immune-modulator which impacts the generation, maturation and activity of many cell types of the innate, as well as the adaptive immune system, including natural killer (NK) and CD8+ T cells. Using a new series of transgenic mice, we analyzed the in vivo potential of IL15 as an immune-regulator when available at different concentrations or delivery modes, i.e. soluble monomer or complexed to its specific receptor a (Ra)-chain. We have identified distinct effects on selected IL15-responsive populations. While CD8+ T cells required complexed forms of IL15/IL15Ra for full functionality, mature NK populations were rescued in an IL15/IL15Ra-deficient environment by high levels of CD11c-restricted IL15. These IL15-conditions were sufficient to limit tumor formation in a lung metastasis model indicating that the NK cell populations were fully functional. These data underline the potential of "free" IL15 in the absence of Ra-complex as a powerful and specific immuno-modulator, which may be beneficial where selective immune-activation is desired.19699-19699Nature Publishing Groupglycoprotein p 15095Il15ra proteinmouseinterleukin 15interleukin 15 receptoranimalantigen presentationCD8+ T lymphocytecell differentiationcytologycytotoxicityexperimental melanomageneticsimmunologyknockout mousemetabolismmetastasismousenatural killer cellneoplasmpathologyPeyer patchphysiologypromoter regionthymustransgenic mousetumor cell lineAnimalsAntigen PresentationAntigensCD11cCD8-Positive T-LymphocytesCell DifferentiationCell LineTumorCytotoxicityImmunologicInterleukin-15Killer CellsNaturalMelanomaExperimentalMiceMiceKnockoutMiceTransgenicNeoplasm MetastasisNeoplasmsPeyer's PatchesPromoter RegionsGeneticReceptorsInterleukin-15Thymus GlandHigh dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent mannerArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionSCI REP-UKinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41677oai:repository.ucc.edu.co:20.500.12494/416772024-08-20 16:20:54.827metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv	High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner
title	High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner
spellingShingle	High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner glycoprotein p 15095 Il15ra protein mouse interleukin 15 interleukin 15 receptor animal antigen presentation CD8+ T lymphocyte cell differentiation cytology cytotoxicity experimental melanoma genetics immunology knockout mouse metabolism metastasis mouse natural killer cell neoplasm pathology Peyer patch physiology promoter region thymus transgenic mouse tumor cell line Animals Antigen Presentation Antigens CD11c CD8-Positive T-Lymphocytes Cell Differentiation Cell Line Tumor Cytotoxicity Immunologic Interleukin-15 Killer Cells Natural Melanoma Experimental Mice Mice Knockout Mice Transgenic Neoplasm Metastasis Neoplasms Peyer's Patches Promoter Regions Genetic Receptors Interleukin-15 Thymus Gland
title_short	High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner
title_full	High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner
title_fullStr	High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner
title_full_unstemmed	High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner
title_sort	High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner
dc.creator.fl_str_mv	Polansky J.K. Bahri R. Divivier M. Duitman E.H. Vock C. Goyeneche Patiño, Diego Andres Orinska Z. Bulfone-Paus S.
dc.contributor.author.none.fl_str_mv	Polansky J.K. Bahri R. Divivier M. Duitman E.H. Vock C. Goyeneche Patiño, Diego Andres Orinska Z. Bulfone-Paus S.
dc.subject.spa.fl_str_mv	glycoprotein p 15095 Il15ra protein mouse interleukin 15 interleukin 15 receptor animal antigen presentation CD8+ T lymphocyte cell differentiation cytology cytotoxicity experimental melanoma genetics immunology knockout mouse metabolism metastasis mouse natural killer cell neoplasm pathology Peyer patch physiology promoter region thymus transgenic mouse tumor cell line Animals Antigen Presentation Antigens CD11c CD8-Positive T-Lymphocytes Cell Differentiation Cell Line Tumor Cytotoxicity Immunologic Interleukin-15 Killer Cells Natural Melanoma Experimental Mice Mice Knockout Mice Transgenic Neoplasm Metastasis Neoplasms Peyer's Patches Promoter Regions Genetic Receptors Interleukin-15 Thymus Gland
topic	glycoprotein p 15095 Il15ra protein mouse interleukin 15 interleukin 15 receptor animal antigen presentation CD8+ T lymphocyte cell differentiation cytology cytotoxicity experimental melanoma genetics immunology knockout mouse metabolism metastasis mouse natural killer cell neoplasm pathology Peyer patch physiology promoter region thymus transgenic mouse tumor cell line Animals Antigen Presentation Antigens CD11c CD8-Positive T-Lymphocytes Cell Differentiation Cell Line Tumor Cytotoxicity Immunologic Interleukin-15 Killer Cells Natural Melanoma Experimental Mice Mice Knockout Mice Transgenic Neoplasm Metastasis Neoplasms Peyer's Patches Promoter Regions Genetic Receptors Interleukin-15 Thymus Gland
description	The common gamma (?c)-chain cytokine interleukin 15 (IL15) is a multifunctional immune-modulator which impacts the generation, maturation and activity of many cell types of the innate, as well as the adaptive immune system, including natural killer (NK) and CD8+ T cells. Using a new series of transgenic mice, we analyzed the in vivo potential of IL15 as an immune-regulator when available at different concentrations or delivery modes, i.e. soluble monomer or complexed to its specific receptor a (Ra)-chain. We have identified distinct effects on selected IL15-responsive populations. While CD8+ T cells required complexed forms of IL15/IL15Ra for full functionality, mature NK populations were rescued in an IL15/IL15Ra-deficient environment by high levels of CD11c-restricted IL15. These IL15-conditions were sufficient to limit tumor formation in a lung metastasis model indicating that the NK cell populations were fully functional. These data underline the potential of "free" IL15 in the absence of Ra-complex as a powerful and specific immuno-modulator, which may be beneficial where selective immune-activation is desired.
publishDate	2016
dc.date.issued.none.fl_str_mv	2016
dc.date.accessioned.none.fl_str_mv	2021-12-16T22:15:42Z
dc.date.available.none.fl_str_mv	2021-12-16T22:15:42Z
dc.type.none.fl_str_mv	Artículo
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/publishedVersion
format	http://purl.org/coar/resource_type/c_6501
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://doi.org/10.14295/bds.2020.v23i3.2055 https://hemeroteca.unad.edu.co/index.php/riaa/article/view/2067
dc.identifier.issn.spa.fl_str_mv	20452322
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/41677
dc.identifier.bibliographicCitation.spa.fl_str_mv	Polansky JK,Bahri R,Divivier M,Duitman EH,Vock C,Goyeneche DA,Orinska Z,Bulfone S. High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner. Sci Rep. 2016. 6. p. 19699-19699. .
url	https://doi.org/10.14295/bds.2020.v23i3.2055 https://hemeroteca.unad.edu.co/index.php/riaa/article/view/2067 https://hdl.handle.net/20.500.12494/41677
identifier_str_mv	20452322 Polansky JK,Bahri R,Divivier M,Duitman EH,Vock C,Goyeneche DA,Orinska Z,Bulfone S. High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner. Sci Rep. 2016. 6. p. 19699-19699. .
dc.relation.ispartofjournal.spa.fl_str_mv	SCI REP-UK
dc.rights.accessrights.none.fl_str_mv	info:eu-repo/semantics/closedAccess
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eu_rights_str_mv	closedAccess
rights_invalid_str_mv	http://purl.org/coar/access_right/c_14cb
dc.format.extent.spa.fl_str_mv	19699-19699
dc.publisher.spa.fl_str_mv	Nature Publishing Group
institution	Universidad Cooperativa de Colombia
repository.name.fl_str_mv	Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv	bdigital@metabiblioteca.com
_version_	1814247090350456832

High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner

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