High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner

The common gamma (?c)-chain cytokine interleukin 15 (IL15) is a multifunctional immune-modulator which impacts the generation, maturation and activity of many cell types of the innate, as well as the adaptive immune system, including natural killer (NK) and CD8+ T cells. Using a new series of transg...

Full description

Autores:

Polansky J.K.
Bahri R.
Divivier M.
Duitman E.H.
Vock C.
Goyeneche Patiño, Diego Andres
Orinska Z.
Bulfone-Paus S.

Tipo de recurso:

Article of journal

Fecha de publicación:

2016

Institución:

Universidad Cooperativa de Colombia

Repositorio:

Repositorio UCC

Idioma:

OAI Identifier:

oai:repository.ucc.edu.co:20.500.12494/41677

Acceso en línea:

https://doi.org/10.14295/bds.2020.v23i3.2055
https://hemeroteca.unad.edu.co/index.php/riaa/article/view/2067
https://hdl.handle.net/20.500.12494/41677

Palabra clave:

glycoprotein p 15095
Il15ra protein
mouse
interleukin 15
interleukin 15 receptor
animal
antigen presentation
CD8+ T lymphocyte
cell differentiation
cytology
cytotoxicity
experimental melanoma
genetics
immunology
knockout mouse
metabolism
metastasis
mouse
natural killer cell
neoplasm
pathology
Peyer patch
physiology
promoter region
thymus
transgenic mouse
tumor cell line
Animals
Antigen Presentation
Antigens
CD11c
CD8-Positive T-Lymphocytes
Cell Differentiation
Cell Line
Tumor
Cytotoxicity
Immunologic
Interleukin-15
Killer Cells
Natural
Melanoma
Experimental
Mice
Mice
Knockout
Mice
Transgenic
Neoplasm Metastasis
Neoplasms
Peyer's Patches
Promoter Regions
Genetic
Receptors
Interleukin-15
Thymus Gland

Rights

closedAccess

License

http://purl.org/coar/access_right/c_14cb