Human macrophages differentiated in the presence of vitamin D3restrict dengue virus infection and innate responses by downregulating mannose receptor expression

Background: Severe dengue disease is associated with high viral loads and overproduction of pro-inflammatory cytokines, suggesting impairment in the control of dengue virus (DENV) and the mechanisms that regulate cytokine production. Vitamin D3has been described as an important modulator of immune r...

Full description

Autores:

Arboleda Alzate J.F.
Rodenhuis-Zybert I.A.
Hernández López, Juan Carlos
Smit J.M.
Urcuqui-Inchima S.

Tipo de recurso:

Article of journal

Fecha de publicación:

2017

Institución:

Universidad Cooperativa de Colombia

Repositorio:

Repositorio UCC

Idioma:

OAI Identifier:

oai:repository.ucc.edu.co:20.500.12494/41881

Acceso en línea:

https://doi.org/10.17533/udea.boan.v32n53a09
https://hdl.handle.net/20.500.12494/41881

Palabra clave:

colecalciferol
interleukin 10
interleukin 1beta
interleukin 6
mannose receptor
tumor necrosis factor
cell surface receptor
colecalciferol
lectin
mannose binding lectin
mannose receptor
Article
blood donor
Dengue virus
down regulation
enzyme linked immunosorbent assay
flow cytometry
gene expression
immune response
inflammation
innate immunity
nonhuman
real time polymerase chain reaction
reverse transcription polymerase chain reaction
virus infection
virus particle
adult
animal
cell differentiation
cell line
Dengue virus
down regulation
drug effects
female
gene expression regulation
genetics
human
innate immunity
macrophage
male
metabolism
mosquito
physiology
virology
virus replication
Adult
Animals
Blood Donors
Cell Differentiation
Cell Line
Cholecalciferol
Culicidae
Dengue Virus
Down-Regulation
Female
Gene Expression Regulation
Humans
Immunity
Innate
Lectins
C-Type
Macrophages
Male
Mannose-Binding Lectins
Receptors
Cell S

Rights

closedAccess

License

http://purl.org/coar/access_right/c_14cb