Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia

Dengue is hyperendemic in Colombia, where a cyclic behavior of serotype replacement leading to periodic epidemics has been observed for decades. This level of endemicity favors accumulation of dengue virus genetic diversity and could be linked to disease outcome. To assess the genetic diversity of d...

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Autores:: Laiton-Donato K.
Alvarez D.A.
Peláez-Carvajal D.
Mercado M.
Ajami N.J.
Bosch I.
Usme Ciro, José Aldemar

Tipo de recurso:: Article of journal

Fecha de publicación:: 2019

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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repository_id_str
spelling	Laiton-Donato K.Alvarez D.A.Peláez-Carvajal D.Mercado M.Ajami N.J.Bosch I.Usme Ciro, José Aldemar2021-12-16T22:15:49Z2021-12-16T22:15:49Z2019https://doi.org/10.16925/ra.v17i31.10961743422Xhttps://hdl.handle.net/20.500.12494/41838Laiton K,Alvarez DA,Peláez D,Mercado M,Ajami NJ,Bosch I,Usme JA. Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia. VIROL J. 2019. 16. (1):p. 62-62. .Dengue is hyperendemic in Colombia, where a cyclic behavior of serotype replacement leading to periodic epidemics has been observed for decades. This level of endemicity favors accumulation of dengue virus genetic diversity and could be linked to disease outcome. To assess the genetic diversity of dengue virus type 2 in Colombia, we sequenced the envelope gene of 24 virus isolates from acute cases of dengue or severe dengue fever during the period 2013-2016. The phylogenetic analysis revealed the circulation of the Asian-American genotype of dengue virus type 2 in Colombia during that period, the intra-genotype variability leading to divergence in two recently circulating lineages with differential geographic distribution, as well as the presence of nonsynonymous substitutions accompanying their emergence and diversification. © 2019 The Author(s).0000-0002-8093-0544jose.usmec@campusucc.edu.co62-62BioMed CentraladolescentadultArticlechildclinical articleColombiaDengue virusenvelope genefemalegene sequencegenetic variabilitygenotypegeographyhumanmalemiddle agednonhumannucleotide sequencephylogenyretrospective studysevere denguevirus characterizationvirus genevirus isolationbiobankblooddengueDengue virusgenetic variationgeneticsgenotypehigh throughput sequencingpreschool childserotypevirologyyoung adultvirus envelope proteinvirus RNAAdolescentAdultBiological Specimen BanksChildChildPreschoolColombiaDengueDengue VirusFemaleGenetic VariationGenotypeHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedPhylogenyRetrospective StudiesRNAViralSerogroupViral Envelope ProteinsYoung AdultMolecular characterization of dengue virus reveals regional diversification of serotype 2 in ColombiaArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionVIROL Jinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41838oai:repository.ucc.edu.co:20.500.12494/418382024-08-20 16:17:10.395metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv	Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
title	Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
spellingShingle	Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia adolescent adult Article child clinical article Colombia Dengue virus envelope gene female gene sequence genetic variability genotype geography human male middle aged nonhuman nucleotide sequence phylogeny retrospective study severe dengue virus characterization virus gene virus isolation biobank blood dengue Dengue virus genetic variation genetics genotype high throughput sequencing preschool child serotype virology young adult virus envelope protein virus RNA Adolescent Adult Biological Specimen Banks Child Child Preschool Colombia Dengue Dengue Virus Female Genetic Variation Genotype High-Throughput Nucleotide Sequencing Humans Male Middle Aged Phylogeny Retrospective Studies RNA Viral Serogroup Viral Envelope Proteins Young Adult
title_short	Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
title_full	Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
title_fullStr	Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
title_full_unstemmed	Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
title_sort	Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
dc.creator.fl_str_mv	Laiton-Donato K. Alvarez D.A. Peláez-Carvajal D. Mercado M. Ajami N.J. Bosch I. Usme Ciro, José Aldemar
dc.contributor.author.none.fl_str_mv	Laiton-Donato K. Alvarez D.A. Peláez-Carvajal D. Mercado M. Ajami N.J. Bosch I. Usme Ciro, José Aldemar
dc.subject.spa.fl_str_mv	adolescent adult Article child clinical article Colombia Dengue virus envelope gene female gene sequence genetic variability genotype geography human male middle aged nonhuman nucleotide sequence phylogeny retrospective study severe dengue virus characterization virus gene virus isolation biobank blood dengue Dengue virus genetic variation genetics genotype high throughput sequencing preschool child serotype virology young adult virus envelope protein virus RNA Adolescent Adult Biological Specimen Banks Child Child Preschool Colombia Dengue Dengue Virus Female Genetic Variation Genotype High-Throughput Nucleotide Sequencing Humans Male Middle Aged Phylogeny Retrospective Studies RNA Viral Serogroup Viral Envelope Proteins Young Adult
topic	adolescent adult Article child clinical article Colombia Dengue virus envelope gene female gene sequence genetic variability genotype geography human male middle aged nonhuman nucleotide sequence phylogeny retrospective study severe dengue virus characterization virus gene virus isolation biobank blood dengue Dengue virus genetic variation genetics genotype high throughput sequencing preschool child serotype virology young adult virus envelope protein virus RNA Adolescent Adult Biological Specimen Banks Child Child Preschool Colombia Dengue Dengue Virus Female Genetic Variation Genotype High-Throughput Nucleotide Sequencing Humans Male Middle Aged Phylogeny Retrospective Studies RNA Viral Serogroup Viral Envelope Proteins Young Adult
description	Dengue is hyperendemic in Colombia, where a cyclic behavior of serotype replacement leading to periodic epidemics has been observed for decades. This level of endemicity favors accumulation of dengue virus genetic diversity and could be linked to disease outcome. To assess the genetic diversity of dengue virus type 2 in Colombia, we sequenced the envelope gene of 24 virus isolates from acute cases of dengue or severe dengue fever during the period 2013-2016. The phylogenetic analysis revealed the circulation of the Asian-American genotype of dengue virus type 2 in Colombia during that period, the intra-genotype variability leading to divergence in two recently circulating lineages with differential geographic distribution, as well as the presence of nonsynonymous substitutions accompanying their emergence and diversification. © 2019 The Author(s).
publishDate	2019
dc.date.issued.none.fl_str_mv	2019
dc.date.accessioned.none.fl_str_mv	2021-12-16T22:15:49Z
dc.date.available.none.fl_str_mv	2021-12-16T22:15:49Z
dc.type.none.fl_str_mv	Artículo
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
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dc.identifier.none.fl_str_mv	https://doi.org/10.16925/ra.v17i31.1096
dc.identifier.issn.spa.fl_str_mv	1743422X
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/41838
dc.identifier.bibliographicCitation.spa.fl_str_mv	Laiton K,Alvarez DA,Peláez D,Mercado M,Ajami NJ,Bosch I,Usme JA. Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia. VIROL J. 2019. 16. (1):p. 62-62. .
url	https://doi.org/10.16925/ra.v17i31.1096 https://hdl.handle.net/20.500.12494/41838
identifier_str_mv	1743422X Laiton K,Alvarez DA,Peláez D,Mercado M,Ajami NJ,Bosch I,Usme JA. Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia. VIROL J. 2019. 16. (1):p. 62-62. .
dc.relation.ispartofjournal.spa.fl_str_mv	VIROL J
dc.rights.accessrights.none.fl_str_mv	info:eu-repo/semantics/closedAccess
dc.rights.coar.none.fl_str_mv	http://purl.org/coar/access_right/c_14cb
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dc.format.extent.spa.fl_str_mv	62-62
dc.publisher.spa.fl_str_mv	BioMed Central
institution	Universidad Cooperativa de Colombia
repository.name.fl_str_mv	Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv	bdigital@metabiblioteca.com
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Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia

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