The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death

Strongyloidiasis is widely distributed in the tropical and subtropical areas. Ivermectin is the drug of choice for the treatment. However, the concerns about relying treatment on a single drug make identification of new molecules a priority. Alkylphospholipid analogues, including edelfosine, are a g...

Full description

Autores:

Legarda-Ceballos A.L.
Rojas Caraballo, Jose Vicente
López-Abán J.
Ruano A.L.
Yepes E.
Gajate C.
Mollinedo F.
Muro A.

Tipo de recurso:

Article of journal

Fecha de publicación:

2016

Institución:

Universidad Cooperativa de Colombia

Repositorio:

Repositorio UCC

Idioma:

OAI Identifier:

oai:repository.ucc.edu.co:20.500.12494/41416

Acceso en línea:

https://doi.org/10.1016/j.dental.2012.09.002
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062607238&doi=10.1371%2fjournal.pone.0213425&partnerID=40&md5=18df756332a9c86d62ca9bbc4087c4d1
https://hdl.handle.net/20.500.12494/41416

Palabra clave:

edelfosine
ivermectin
miltefosine
perifosine
antineoplastic agent
edelfosine
ether phospholipid
phosphorylcholine
apoptosis
DNA
drug
fragmentation
larva
nematode
parasite
phospholipid
animal cell
animal experiment
animal model
antiprotozoal activity
apoptosis
Article
cell count
DNA fragmentation
drug cytotoxicity
drug efficacy
drug response
drug structure
drug tolerability
endothelium cell
fibroblast
IC50
in vitro study
in vivo study
larva
LD50
liver cell
mouse
nonhuman
Strongyloides venezuelensis
strongyloidiasis
treatment duration
analogs and derivatives
animal
dose response
drug effects
female
parasitology
Strongyloides
strongyloidiasis
Mus
Strongyloides venezuelensis
Animals
Antineoplastic Agents
Apoptosis
Dose-Response Relationship
Drug
Female
Larva
Mice
Phospholipid Ethers
Phosphorylcholine
Strongyloides
Strongyloidiasis

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closedAccess

License

http://purl.org/coar/access_right/c_14cb