Convalescent plasma in Covid-19: Possible mechanisms of action.

 

Authors
Rojas, Manuel; Rodriguez, Yhojan; Monsalve, Diana M; Acosta-Ampudia, Yeny; Camacho, Bernardo; Gallo, Juan Esteban; Rojas-Villarraga, Adriana; Ramirez-Santana, Carolina; Diaz-Coronado, Juan C; Manrique, Ruben; Mantilla, Ruben D; Shoenfeld, Yehuda; Anaya, Juan-Manuel
Format
Article
Status
Published version
Description

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible of the coronavirus disease 2019 (COVID-19) pandemic. Therapeutic options including antimalarials, antivirals, and vaccines are under study. Meanwhile the current pandemic has called attention over old therapeutic tools to treat infectious diseases. Convalescent plasma (CP) constitutes the first option in the current situation, since it has been successfully used in other coronaviruses outbreaks. Herein, we discuss the possible mechanisms of action of CP and their repercussion in COVID-19 pathogenesis, including direct neutralization of the virus, control of an overactive immune system (i.e., cytokine storm, Th1/Th17 ratio, complement activation) and immunomodulation of a hypercoagulable state. All these benefits of CP are expected to be better achieved if used in non-critically hospitalized patients, in the hope of reducing morbidity and mortality.

Publication Year
2020
Language
English
Topic
ACE-2 receptor
COVID-19
Convalescent plasma
Coronavirus
Cytokines
Intravenous immunoglobulins
Neutralizing antibodies
SARS-Cov-2
Repository
Repositorio EdocUR - U. Rosario
Get full text
https://repository.urosario.edu.co/handle/10336/24587
https://doi.org/10.1016/j.autrev.2020.102554
Rights
Open access
License