CAR-NK cells: A model for tumor immunotherapy. Literature review

The objective of this review is to describe the biological, immunological, and oncological principles that are associated with the theoretical basis for the use of CAR-NK cells for tumor immunotherapy. Since the discovery of natural killer cells (in English Natural Killer Cells or NK cells), great a...

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Autores:
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Pontificia Universidad Javeriana Cali
Repositorio:
Vitela
Idioma:
spa
OAI Identifier:
oai:vitela.javerianacali.edu.co:11522/510
Acceso en línea:
https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1294
https://vitela.javerianacali.edu.co/handle/11522/510
Palabra clave:
Células asesinas naturales
Receptores quiméricos de antígenos
Inmunoterapia
Tumor
Cáncer
Natural killer cells
Chimeric antigen receptors
Immunotherapy
Tumor
Cancer
Rights
License
Derechos de autor 2023 Salutem Scientia Spiritus
id Vitela2_e895045c6e830efc368271ab8ff255d7
oai_identifier_str oai:vitela.javerianacali.edu.co:11522/510
network_acronym_str Vitela2
network_name_str Vitela
repository_id_str
spelling Betancourt-Plaza, John DarowinOrtega-Ávila, José Guillermo2021-12-302023-10-11T04:35:16Z2023-10-11T04:35:16Zhttps://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1294https://vitela.javerianacali.edu.co/handle/11522/510The objective of this review is to describe the biological, immunological, and oncological principles that are associated with the theoretical basis for the use of CAR-NK cells for tumor immunotherapy. Since the discovery of natural killer cells (in English Natural Killer Cells or NK cells), great advances have been made in the understanding of the mechanisms of action, and their functions related to the immune system. This knowledge has led to the development of promising technologies and therapies, such as those based on genetically modified NK cells with chimeric antigen receptors (CARs) called CAR-NK cells that were originally designed for the treatment of different types of cancer, showing potential results in animal models. It is expected that the clinical trials that are being developed will yield positive results for CAR-NK cells, allowing us to know the advantages and disadvantages of this type of immunotherapy.El objetivo de esta revisión es describir los principios biológicos, inmunológicos, y oncológicos que, están asociados, con la fundamentación teórica de la utilización de las células CAR-NK, para la inmunoterapia tumoral. Desde el descubrimiento de las células asesinas naturales (en inglés Natural Killer Cells o células NK), se han presentado grandes avances en la comprensión de los mecanismos acción, y sus funciones relacionadas con el sistema inmunológico. Este conocimiento ha dado paso al desarrollo de las tecnologías y terapias prometedoras, como las basadas en las células NK modificadas genéticamente con los receptores quiméricos de antígenos (en inglés Chimeric Antigen Receptors o CAR) denominadas, por sus siglas en inglés, células CAR-NK que originalmente fueron diseñadas, para el tratamiento de diferentes tipos de cáncer, mostrando resultados potenciales en modelos animales. Se espera que los ensayos clínicos que se están desarrollando arrojen resultados positivos de las células CAR-NK, permitiendo conocer las ventajas y desventajas de este tipo de inmunoterapia.application/pdfspaPontificia Universidad Javeriana Calihttps://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1294/1129Derechos de autor 2023 Salutem Scientia Spiritushttps://creativecommons.org/licenses/by-nc-nd/4.0Salutem Scientia Spiritus; Vol. 7 No. 4 (2021): Revista Salutem Scientia Spiritus; 83-91Salutem Scientia Spiritus; Vol. 7 Núm. 4 (2021): Revista Salutem Scientia Spiritus; 83-912463-1426Células asesinas naturalesReceptores quiméricos de antígenosInmunoterapiaTumorCáncerNatural killer cellsChimeric antigen receptorsImmunotherapyTumorCancerCAR-NK cells: A model for tumor immunotherapy. Literature reviewCélulas CAR-NK: Un modelo para la inmunoterapia tumoral. Revisión de la literaturainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisión de la literatura11522/510oai:vitela.javerianacali.edu.co:11522/5102024-06-25 05:12:43.349metadata.onlyhttps://vitela.javerianacali.edu.coRepositorio Vitelavitela.mail@javerianacali.edu.co
dc.title.en-US.fl_str_mv CAR-NK cells: A model for tumor immunotherapy. Literature review
dc.title.es-ES.fl_str_mv Células CAR-NK: Un modelo para la inmunoterapia tumoral. Revisión de la literatura
title CAR-NK cells: A model for tumor immunotherapy. Literature review
spellingShingle CAR-NK cells: A model for tumor immunotherapy. Literature review
Betancourt-Plaza, John Darowin
Células asesinas naturales
Receptores quiméricos de antígenos
Inmunoterapia
Tumor
Cáncer
Natural killer cells
Chimeric antigen receptors
Immunotherapy
Tumor
Cancer
title_short CAR-NK cells: A model for tumor immunotherapy. Literature review
title_full CAR-NK cells: A model for tumor immunotherapy. Literature review
title_fullStr CAR-NK cells: A model for tumor immunotherapy. Literature review
title_full_unstemmed CAR-NK cells: A model for tumor immunotherapy. Literature review
title_sort CAR-NK cells: A model for tumor immunotherapy. Literature review
dc.creator.none.fl_str_mv Betancourt-Plaza, John Darowin
Ortega-Ávila, José Guillermo
author Betancourt-Plaza, John Darowin
author_facet Betancourt-Plaza, John Darowin
Ortega-Ávila, José Guillermo
author_role author
author2 Ortega-Ávila, José Guillermo
author2_role author
dc.subject.es-ES.fl_str_mv Células asesinas naturales
Receptores quiméricos de antígenos
Inmunoterapia
Tumor
Cáncer
topic Células asesinas naturales
Receptores quiméricos de antígenos
Inmunoterapia
Tumor
Cáncer
Natural killer cells
Chimeric antigen receptors
Immunotherapy
Tumor
Cancer
dc.subject.en-US.fl_str_mv Natural killer cells
Chimeric antigen receptors
Immunotherapy
Tumor
Cancer
description The objective of this review is to describe the biological, immunological, and oncological principles that are associated with the theoretical basis for the use of CAR-NK cells for tumor immunotherapy. Since the discovery of natural killer cells (in English Natural Killer Cells or NK cells), great advances have been made in the understanding of the mechanisms of action, and their functions related to the immune system. This knowledge has led to the development of promising technologies and therapies, such as those based on genetically modified NK cells with chimeric antigen receptors (CARs) called CAR-NK cells that were originally designed for the treatment of different types of cancer, showing potential results in animal models. It is expected that the clinical trials that are being developed will yield positive results for CAR-NK cells, allowing us to know the advantages and disadvantages of this type of immunotherapy.
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2023-10-11T04:35:16Z
dc.date.available.none.fl_str_mv 2023-10-11T04:35:16Z
dc.date.none.fl_str_mv 2021-12-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
dc.type.es-ES.fl_str_mv Revisión de la literatura
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1294
dc.identifier.uri.none.fl_str_mv https://vitela.javerianacali.edu.co/handle/11522/510
url https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1294
https://vitela.javerianacali.edu.co/handle/11522/510
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1294/1129
dc.rights.es-ES.fl_str_mv Derechos de autor 2023 Salutem Scientia Spiritus
https://creativecommons.org/licenses/by-nc-nd/4.0
rights_invalid_str_mv Derechos de autor 2023 Salutem Scientia Spiritus
https://creativecommons.org/licenses/by-nc-nd/4.0
dc.format.none.fl_str_mv application/pdf
dc.publisher.es-ES.fl_str_mv Pontificia Universidad Javeriana Cali
dc.source.en-US.fl_str_mv Salutem Scientia Spiritus; Vol. 7 No. 4 (2021): Revista Salutem Scientia Spiritus; 83-91
dc.source.es-ES.fl_str_mv Salutem Scientia Spiritus; Vol. 7 Núm. 4 (2021): Revista Salutem Scientia Spiritus; 83-91
dc.source.none.fl_str_mv 2463-1426
institution Pontificia Universidad Javeriana Cali
repository.name.fl_str_mv Repositorio Vitela
repository.mail.fl_str_mv vitela.mail@javerianacali.edu.co
_version_ 1812095047851573248

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