Paracetamol poisoning in an adult patient: Case report and review of literature.

The acetaminophen (acetyl para-aminophenol n-) is a para-aminophenol derivative as phenacetin, maintaining, as this antipyretic and analgesic effect, besides antiinflammatory effects. It is a drug widely used in both adult and pediatric population. Previous studies of secondary poisoning consumption...

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Autores:
Tipo de recurso:
Fecha de publicación:
2022
Institución:
Pontificia Universidad Javeriana Cali
Repositorio:
Vitela
Idioma:
spa
OAI Identifier:
oai:vitela.javerianacali.edu.co:11522/457
Acceso en línea:
https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/651
https://vitela.javerianacali.edu.co/handle/11522/457
Palabra clave:
Paracetamol
Intoxicación
Falla hepática
Encefalopatía
N-acetilcisteína
Paracetamol
Poisoning
Liver Failure
Encephalopathy
N-acetyl cysteine
Rights
License
Derechos de autor 2023 Salutem Scientia Spiritus
id Vitela2_ce67706d175f249b33088608c52b8341
oai_identifier_str oai:vitela.javerianacali.edu.co:11522/457
network_acronym_str Vitela2
network_name_str Vitela
repository_id_str
spelling Charria, LaurentCorrea, DanielOsorio, LauraSandoval, DavidSaldaña-Campos, Javier2022-09-302023-10-11T04:34:58Z2023-10-11T04:34:58Zhttps://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/651https://vitela.javerianacali.edu.co/handle/11522/457The acetaminophen (acetyl para-aminophenol n-) is a para-aminophenol derivative as phenacetin, maintaining, as this antipyretic and analgesic effect, besides antiinflammatory effects. It is a drug widely used in both adult and pediatric population. Previous studies of secondary poisoning consumption of this drug demonstrate that adult dose is 6 to 7 grams potentially having a possible toxic effect, the lethal dose is about 13 to 25 grams. In this paper we report the case of a 28-year-old female patient who consumes 36 paracetamol tablets (18 grams) due to a suicide attempt, which is carried out by internal medicine together with social work, psychology, and psychiatry. Management with saline solution, metoclopramide and N-acetylcysteine is started. The patient showed multiorgan compromise, acute hepatic failure, electrolyte imbalance, and psychotic symptoms, with evidence of neurological compromise.El paracetamol o acetaminofén (n-acetil-para-aminofenol) es un derivado del paraaminofenol al igual que la fenacetina, manteniendo, como está un efecto antipirético y analgésico, además de efectos antiinflamatorios. Es un medicamento de amplio uso tanto en la población adulta como pediátrica. Estudios anteriores de intoxicaciones secundarias al consumo de este fármaco demuestran que la dosis en adultos es de 6 a 7 gramos teniendo un posible efecto potencialmente tóxico, su dosis letal es de alrededor 13 a 25 gramos. En este documento reportamos el caso de una paciente femenina de 28 años quien por intento suicida consume 36 tabletas de paracetamol (18 gramos), la cual se lleva a cabo por medicina interna junto con trabajo social, psicología y psiquiatría. Se inicia manejo con solución salina, metoclopramida y N-acetilcisteína. La paciente da como resultado un compromiso multiorgánico, falla hepática aguda, desequilibrio electrolítico, además de síntomas psicóticos, donde se evidencia compromiso neurológico.application/pdfspaPontificia Universidad Javeriana Calihttps://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/651/554Derechos de autor 2023 Salutem Scientia Spiritushttps://creativecommons.org/licenses/by-nc-nd/4.0Salutem Scientia Spiritus; Vol. 8 No. 3 (2022): Revista Salutem Scientia Spiritus; 112-118Salutem Scientia Spiritus; Vol. 8 Núm. 3 (2022): Revista Salutem Scientia Spiritus; 112-1182463-1426ParacetamolIntoxicaciónFalla hepáticaEncefalopatíaN-acetilcisteínaParacetamolPoisoningLiver FailureEncephalopathyN-acetyl cysteineParacetamol poisoning in an adult patient: Case report and review of literature.Intoxicación por paracetamol en paciente adulto: reporte de caso y revisión de la literatura.info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionReporte de caso11522/457oai:vitela.javerianacali.edu.co:11522/4572024-06-25 05:12:42.507metadata.onlyhttps://vitela.javerianacali.edu.coRepositorio Vitelavitela.mail@javerianacali.edu.co
dc.title.en-US.fl_str_mv Paracetamol poisoning in an adult patient: Case report and review of literature.
dc.title.es-ES.fl_str_mv Intoxicación por paracetamol en paciente adulto: reporte de caso y revisión de la literatura.
title Paracetamol poisoning in an adult patient: Case report and review of literature.
spellingShingle Paracetamol poisoning in an adult patient: Case report and review of literature.
Charria, Laurent
Paracetamol
Intoxicación
Falla hepática
Encefalopatía
N-acetilcisteína
Paracetamol
Poisoning
Liver Failure
Encephalopathy
N-acetyl cysteine
title_short Paracetamol poisoning in an adult patient: Case report and review of literature.
title_full Paracetamol poisoning in an adult patient: Case report and review of literature.
title_fullStr Paracetamol poisoning in an adult patient: Case report and review of literature.
title_full_unstemmed Paracetamol poisoning in an adult patient: Case report and review of literature.
title_sort Paracetamol poisoning in an adult patient: Case report and review of literature.
dc.creator.none.fl_str_mv Charria, Laurent
Correa, Daniel
Osorio, Laura
Sandoval, David
Saldaña-Campos, Javier
author Charria, Laurent
author_facet Charria, Laurent
Correa, Daniel
Osorio, Laura
Sandoval, David
Saldaña-Campos, Javier
author_role author
author2 Correa, Daniel
Osorio, Laura
Sandoval, David
Saldaña-Campos, Javier
author2_role author
author
author
author
dc.subject.es-ES.fl_str_mv Paracetamol
Intoxicación
Falla hepática
Encefalopatía
N-acetilcisteína
topic Paracetamol
Intoxicación
Falla hepática
Encefalopatía
N-acetilcisteína
Paracetamol
Poisoning
Liver Failure
Encephalopathy
N-acetyl cysteine
dc.subject.en-US.fl_str_mv Paracetamol
Poisoning
Liver Failure
Encephalopathy
N-acetyl cysteine
description The acetaminophen (acetyl para-aminophenol n-) is a para-aminophenol derivative as phenacetin, maintaining, as this antipyretic and analgesic effect, besides antiinflammatory effects. It is a drug widely used in both adult and pediatric population. Previous studies of secondary poisoning consumption of this drug demonstrate that adult dose is 6 to 7 grams potentially having a possible toxic effect, the lethal dose is about 13 to 25 grams. In this paper we report the case of a 28-year-old female patient who consumes 36 paracetamol tablets (18 grams) due to a suicide attempt, which is carried out by internal medicine together with social work, psychology, and psychiatry. Management with saline solution, metoclopramide and N-acetylcysteine is started. The patient showed multiorgan compromise, acute hepatic failure, electrolyte imbalance, and psychotic symptoms, with evidence of neurological compromise.
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2023-10-11T04:34:58Z
dc.date.available.none.fl_str_mv 2023-10-11T04:34:58Z
dc.date.none.fl_str_mv 2022-09-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
dc.type.es-ES.fl_str_mv Reporte de caso
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/651
dc.identifier.uri.none.fl_str_mv https://vitela.javerianacali.edu.co/handle/11522/457
url https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/651
https://vitela.javerianacali.edu.co/handle/11522/457
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/651/554
dc.rights.es-ES.fl_str_mv Derechos de autor 2023 Salutem Scientia Spiritus
https://creativecommons.org/licenses/by-nc-nd/4.0
rights_invalid_str_mv Derechos de autor 2023 Salutem Scientia Spiritus
https://creativecommons.org/licenses/by-nc-nd/4.0
dc.format.none.fl_str_mv application/pdf
dc.publisher.es-ES.fl_str_mv Pontificia Universidad Javeriana Cali
dc.source.en-US.fl_str_mv Salutem Scientia Spiritus; Vol. 8 No. 3 (2022): Revista Salutem Scientia Spiritus; 112-118
dc.source.es-ES.fl_str_mv Salutem Scientia Spiritus; Vol. 8 Núm. 3 (2022): Revista Salutem Scientia Spiritus; 112-118
dc.source.none.fl_str_mv 2463-1426
institution Pontificia Universidad Javeriana Cali
repository.name.fl_str_mv Repositorio Vitela
repository.mail.fl_str_mv vitela.mail@javerianacali.edu.co
_version_ 1812095067117060096

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