Role of chimerism versus immunosuppressive drug therapy in kidney transplant survival: Scoping Review
Aim: To compare the efficacy of chimerism with immunosuppressive drug therapy for kidney transplant survival. Materials and methods: A systematic search of the literature was carried out in Medline, using the PRISMA statement guidelines and the MeSH-type health descriptors. The criteria used for the...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Pontificia Universidad Javeriana Cali
- Repositorio:
- Vitela
- Idioma:
- spa
- OAI Identifier:
- oai:vitela.javerianacali.edu.co:11522/507
- Acceso en línea:
- https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1291
https://vitela.javerianacali.edu.co/handle/11522/507
- Palabra clave:
- Transplante renal
Quimerismo
Tolerancia inmunológica
Supervivencia del injerto
Kidney transplantation
Chimerism
Immune tolerance
Graft survival
- Rights
- License
- Derechos de autor 2023 Salutem Scientia Spiritus
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| dc.title.en-US.fl_str_mv |
Role of chimerism versus immunosuppressive drug therapy in kidney transplant survival: Scoping Review |
| dc.title.es-ES.fl_str_mv |
Papel del quimerismo versus la terapia farmacológica inmunosupresora en la supervivencia al trasplante renal: Revisión exploratoria |
| title |
Role of chimerism versus immunosuppressive drug therapy in kidney transplant survival: Scoping Review |
| spellingShingle |
Role of chimerism versus immunosuppressive drug therapy in kidney transplant survival: Scoping Review Baquero-Tabares, Laura Transplante renal Quimerismo Tolerancia inmunológica Supervivencia del injerto Kidney transplantation Chimerism Immune tolerance Graft survival |
| title_short |
Role of chimerism versus immunosuppressive drug therapy in kidney transplant survival: Scoping Review |
| title_full |
Role of chimerism versus immunosuppressive drug therapy in kidney transplant survival: Scoping Review |
| title_fullStr |
Role of chimerism versus immunosuppressive drug therapy in kidney transplant survival: Scoping Review |
| title_full_unstemmed |
Role of chimerism versus immunosuppressive drug therapy in kidney transplant survival: Scoping Review |
| title_sort |
Role of chimerism versus immunosuppressive drug therapy in kidney transplant survival: Scoping Review |
| dc.creator.none.fl_str_mv |
Baquero-Tabares, Laura Hurtado-Alviz, Isabella Astudillo-Torres, Clara Alexandra Moreno-Correa, Sandra Milena |
| author |
Baquero-Tabares, Laura |
| author_facet |
Baquero-Tabares, Laura Hurtado-Alviz, Isabella Astudillo-Torres, Clara Alexandra Moreno-Correa, Sandra Milena |
| author_role |
author |
| author2 |
Hurtado-Alviz, Isabella Astudillo-Torres, Clara Alexandra Moreno-Correa, Sandra Milena |
| author2_role |
author author author |
| dc.subject.es-ES.fl_str_mv |
Transplante renal Quimerismo Tolerancia inmunológica Supervivencia del injerto |
| topic |
Transplante renal Quimerismo Tolerancia inmunológica Supervivencia del injerto Kidney transplantation Chimerism Immune tolerance Graft survival |
| dc.subject.en-US.fl_str_mv |
Kidney transplantation Chimerism Immune tolerance Graft survival |
| description |
Aim: To compare the efficacy of chimerism with immunosuppressive drug therapy for kidney transplant survival. Materials and methods: A systematic search of the literature was carried out in Medline, using the PRISMA statement guidelines and the MeSH-type health descriptors. The criteria used for the selection of articles were studies conducted in humans, in English or Spanish and published between 1995 and 2020. Results: Twenty-two articles published between 1995 to 2020 were included. The majority of studies used some cytoreductive conditioning regimen prior to combined kidney and hematopoietic stem cell transplantation. For chimerism, the majority achieved a mixed or complete chimeric state. The average of immunosuppressive drug withdrawal after renal and hematopoietic stem cell transplantation was 2.4 months, and was maintained for 4 to 55 months, with satisfactory recovery of renal function and no evidence of rejection episodes. Finally, 22 articles included in this review concluded that chimerism has a role in inducing immune tolerance that improves kidney survival in patients undergoing kidney transplantation. Conclusions: Mixed chimerism induces immunological tolerance that translates into stable kidney function, lower rejection rates, and longer kidney graft survival, without the need for maintenance immunosuppressive therapy. |
| publishDate |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2023-10-11T04:35:14Z |
| dc.date.available.none.fl_str_mv |
2023-10-11T04:35:14Z |
| dc.date.none.fl_str_mv |
2021-12-30 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| dc.type.es-ES.fl_str_mv |
Revisión de la literatura |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1291 |
| dc.identifier.uri.none.fl_str_mv |
https://vitela.javerianacali.edu.co/handle/11522/507 |
| url |
https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1291 https://vitela.javerianacali.edu.co/handle/11522/507 |
| dc.language.none.fl_str_mv |
spa |
| language |
spa |
| dc.relation.none.fl_str_mv |
https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1291/1125 |
| dc.rights.es-ES.fl_str_mv |
Derechos de autor 2023 Salutem Scientia Spiritus https://creativecommons.org/licenses/by-nc-nd/4.0 |
| rights_invalid_str_mv |
Derechos de autor 2023 Salutem Scientia Spiritus https://creativecommons.org/licenses/by-nc-nd/4.0 |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.es-ES.fl_str_mv |
Pontificia Universidad Javeriana Cali |
| dc.source.en-US.fl_str_mv |
Salutem Scientia Spiritus; Vol. 7 No. 4 (2021): Revista Salutem Scientia Spiritus; 49-63 |
| dc.source.es-ES.fl_str_mv |
Salutem Scientia Spiritus; Vol. 7 Núm. 4 (2021): Revista Salutem Scientia Spiritus; 49-63 |
| dc.source.none.fl_str_mv |
2463-1426 |
| institution |
Pontificia Universidad Javeriana Cali |
| repository.name.fl_str_mv |
Repositorio Vitela |
| repository.mail.fl_str_mv |
vitela.mail@javerianacali.edu.co |
| _version_ |
1812095061514518528 |
| spelling |
Baquero-Tabares, LauraHurtado-Alviz, IsabellaAstudillo-Torres, Clara AlexandraMoreno-Correa, Sandra Milena2021-12-302023-10-11T04:35:14Z2023-10-11T04:35:14Zhttps://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1291https://vitela.javerianacali.edu.co/handle/11522/507Aim: To compare the efficacy of chimerism with immunosuppressive drug therapy for kidney transplant survival. Materials and methods: A systematic search of the literature was carried out in Medline, using the PRISMA statement guidelines and the MeSH-type health descriptors. The criteria used for the selection of articles were studies conducted in humans, in English or Spanish and published between 1995 and 2020. Results: Twenty-two articles published between 1995 to 2020 were included. The majority of studies used some cytoreductive conditioning regimen prior to combined kidney and hematopoietic stem cell transplantation. For chimerism, the majority achieved a mixed or complete chimeric state. The average of immunosuppressive drug withdrawal after renal and hematopoietic stem cell transplantation was 2.4 months, and was maintained for 4 to 55 months, with satisfactory recovery of renal function and no evidence of rejection episodes. Finally, 22 articles included in this review concluded that chimerism has a role in inducing immune tolerance that improves kidney survival in patients undergoing kidney transplantation. Conclusions: Mixed chimerism induces immunological tolerance that translates into stable kidney function, lower rejection rates, and longer kidney graft survival, without the need for maintenance immunosuppressive therapy.Objetivo: Comparar la eficacia del quimerismo con la terapia farmacológica de inmunosupresión para la supervivencia del trasplante renal. Materiales y métodos: Se realizó una búsqueda sistemática de la literatura en Medline, mediante las pautas de la declaración PRISMA y los descriptores en salud tipo MeSH. Los criterios utilizados para la selección de artículos fueron, estudios realizados en humanos, en idioma inglés o español y publicados entre 1995 a 2020. Resultados: Se incluyeron 22 artículos publicados entre los años 1995 a 2020. La mayoría de estudios utilizaron algún régimen de condicionamiento citorreductivo previo al trasplante combinado de riñón y células madre hematopoyéticas. En cuanto al quimerismo, la mayoría logró alcanzar un estado quimérico mixto o completo. El promedio de retirada de la terapia inmunosupresora después del trasplante renal y de células madre hematopoyéticas fue 2,4 meses y se mantuvo durante 4 a 55 meses, con recuperación satisfactoria de la función renal y sin evidencia de episodios de rechazo. Finalmente, los 22 artículos incluidos en esta revisión, concluyeron que el quimerismo tiene un papel en la inducción de tolerancia inmunológica que mejora la supervivencia renal en pacientes sometidos a trasplante renal. Conclusiones: El quimerismo mixto induce tolerancia inmunológica que se traduce en estabilidad de la función renal, menores tasas de rechazo y mayor supervivencia del injerto renal, sin necesidad de usar terapia inmunosupresora de mantenimiento.application/pdfspaPontificia Universidad Javeriana Calihttps://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1291/1125Derechos de autor 2023 Salutem Scientia Spiritushttps://creativecommons.org/licenses/by-nc-nd/4.0Salutem Scientia Spiritus; Vol. 7 No. 4 (2021): Revista Salutem Scientia Spiritus; 49-63Salutem Scientia Spiritus; Vol. 7 Núm. 4 (2021): Revista Salutem Scientia Spiritus; 49-632463-1426Transplante renalQuimerismoTolerancia inmunológicaSupervivencia del injertoKidney transplantationChimerismImmune toleranceGraft survivalRole of chimerism versus immunosuppressive drug therapy in kidney transplant survival: Scoping ReviewPapel del quimerismo versus la terapia farmacológica inmunosupresora en la supervivencia al trasplante renal: Revisión exploratoriainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisión de la literatura11522/507oai:vitela.javerianacali.edu.co:11522/5072024-06-25 05:12:43.29metadata.onlyhttps://vitela.javerianacali.edu.coRepositorio Vitelavitela.mail@javerianacali.edu.co |